Evidence map›Paper›PMID 28182191›Full record

ArticleMolecular medicine (Cambridge, Mass.)2017

miR-155 Modifies Inflammation, Endothelial Activation and Blood-Brain Barrier Dysfunction in Cerebral Malaria.

Kevin Richard Barker, Ziyue Lu, Hani Kim, Ying Zheng, Junmei Chen, Andrea L Conroy, Michael Hawkes, Henry S Cheng, Makon-Sébastien Njock, Jason E Fish and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine (Cambridge, Mass.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
7.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Article
  7. New therapeutic strategies for malaria.Biophysical reviews · 2025
    Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Diagnosis of cerebral malaria: Tools to reduceFrontiers in cellular and infection microbiology · 2023
    Review
  16. Article
  17. Review
  18. Review
  19. Non-coding RNAs in malaria infection.Wiley interdisciplinary reviews. RNA · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 2 countries.

Kevin Richard BarkerDepartment of Laboratory Medicine and Pathobiology, University of Toronto, ON, Canada.
Ziyue LuSandra Rotman Centre for Global Health, University Health Network-Toronto General Hospital, and the Tropical Disease Unit, Department of Medicine, University of Toronto, ON, Canada.
Hani KimSandra Rotman Centre for Global Health, University Health Network-Toronto General Hospital, and the Tropical Disease Unit, Department of Medicine, University of Toronto, ON, Canada.
Ying ZhengDepartment of Bioengineering, University of Washington, Seattle, WA, USA; Center of Cardiovascular Biology, Institute of Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA.
Junmei ChenBloodworks Northwest Research Institute, Seattle, WA, USA.
Andrea L ConroySandra Rotman Centre for Global Health, University Health Network-Toronto General Hospital, and the Tropical Disease Unit, Department of Medicine, University of Toronto, ON, Canada.
Michael HawkesDivision of Infectious Diseases, Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Henry S ChengDepartment of Laboratory Medicine and Pathobiology, University of Toronto, ON, Canada.
Makon-Sébastien NjockToronto General Research Institute, University Health Network, Toronto, ON, Canada; Heart and Stroke Richard Lewar Centre of Excellence in Cardiovascular Research, Toronto, ON, Canada.
Jason E FishDepartment of Laboratory Medicine and Pathobiology, University of Toronto, ON, Canada.
John M HarlanDepartment of Medicine, University of Washington, Seattle, WA, USA.
Jose A LópezBloodworks Northwest Research Institute, Seattle, WA, USA.
W Conrad LilesDepartment of Medicine, University of Washington, Seattle, WA, USA.
Kevin C KainDepartment of Laboratory Medicine and Pathobiology, University of Toronto, ON, Canada.
University of Toronto · CAUniversity of Washington · USBloodworks Northwest · USUniversity Health Network · CAHeart and Stroke Foundation · CAToronto General Hospital · CAUniversity of Alberta · CA

Funding

A Microfluidic Bone Marrow Niche for the Study of HematopoiesisDP2DK102258 · NIDDK · UNIVERSITY OF WASHINGTON · PI ZHENG, YING · 2013 to 2013
$2.6M
NIDDK NIH HHS DP2 DK102258
6 · The paper itself

Abstract

miR-155 has been shown to participate in host response to infection and neuro-inflammation via negative regulation of blood-brain-barrier (BBB) integrity and T cell function. We hypothesized that miR-155 may contribute to the pathogenesis of cerebral malaria (CM). To test this hypothesis, we used a genetic approach to modulate miR-155 expression in an experimental model of cerebral malaria (ECM). In addition, an engineered endothelialized microvessel system and serum samples from Ugandan children with CM were used to examine an anti-miR-155 as a potential adjunctive therapeutic for severe malaria. Despite higher parasitemia, survival was significantly improved in

Indexed as

antagomircerebral malariamicroRNAsmicrovesselsplasmodium

Identifiers

PMID28182191
PMCPMC5364112
OpenAlexW2591751046

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.