ArticleJournal of pain research2017
Therapeutic effect of epidural hyaluronic acid in a rat model of foraminal stenosis.
Article in Journal of pain research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Development of a reliable mouse model for caudal epidural anesthesia.Scientific reports · 2025Article
- Repeated epidural delivery of Shinbaro2: effects on neural recovery, inflammation, and pain modulation in a rat model of lumbar spinal stenosis.Frontiers in pharmacology · 2024Article
- Development of a Deep Learning Model for the Analysis of Dorsal Root Ganglion Chromatolysis in Rat Spinal Stenosis.Journal of pain research · 2024Article
- Article
- Epidural and Intrathecal Drug Delivery in Rats and Mice for Experimental Research: Fundamental Concepts, Techniques, Precaution, and Application.Biomedicines · 2023Review
- Epidural Injection Method for Long-Term Pain Management in Rats with Spinal Stenosis.Biomedicines · 2023Article
- Article
- Effect of epidural polydeoxyribonucleotide in a rat model of lumbar foraminal stenosis.The Korean journal of pain · 2021Article
- Successful treatment of unilateral neck pain with transforaminal epidural steroid injection on the left C3 nerve root: a case report.The Journal of international medical research · 2020Article
- Emodin promotes fibroblast apoptosis and prevents epidural fibrosis through PERK pathway in rats.Journal of orthopaedic surgery and research · 2019Article
- Role of NaNeuroscience · 2019Article
- Increased cerebral nuclear factor kappa B in a complex regional pain syndrome rat model: possible relationship between peripheral injury and the brain.Journal of pain research · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSince receiving a warning from the US Food and Drug Administration (FDA) about injection of corticosteroids into the epidural space having serious adverse events, we have sought alternative medications for injection at this site. Hyaluronic acid (HA) has anti-adhesive, anti-inflammatory, and lubricating properties, so could potentially be useful for spinal pain. The exact mechanism by which spinal stenosis develops is not fully understood, but is likely to involve inflammation. Therefore, we hypothesized that HA could have a therapeutic effect in spinal stenosis. This study evaluated the effects of epidural administration of HA on alleviation of pain in a rat model of foraminal stenosis. MATERIALS AND
methodsAfter creating the animal model, HA (HA group) or saline solution (S group) was administered via an epidural catheter. The paw-withdrawal threshold to mechanical stimulation and motor dysfunction were monitored for up to 21 days. Tissue was collected to evaluate the degree of adhesion, inflammation in the perineural area, and chromatolysis in the dorsal root ganglion (DRG).
resultsThe mechanical withdrawal threshold was restored in the HA group but not in the S group (
conclusionHA administered epidurally had a therapeutic effect on the allodynia and hyperalgesia induced by chronic compression of the DRG.
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