ArticleJournal of cytology
Study of nuclear morphometry on cytology specimens of benign and malignant breast lesions: A study of 122 cases.
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Who cites it
14 citing papers in PubMed.
- Spatially Resolved Single-Cell Morphometry of Benign Breast Disease Biopsy Images Uncovers Quantitative Cytomorphometric Features Predictive of Subsequent Invasive Breast Cancer Risk.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2025Article
- Evaluation of Clinicopathological Features in Breast Cancer Patients Using Cytonuclear Morphometry.Maedica · 2024Article
- Clinical values of nuclear morphometric analysis in fibroepithelial lesions.Breast cancer research : BCR · 2024Article
- Distinctive field effects of smoking and lung cancer case-control status on bronchial basal cell growth and signaling.Respiratory research · 2024Article
- In Vitro Assessment of the Cytotoxic Effect of 5-Fluorouracil, Thymoquinone and their Combination on Tongue Squamous Cell Carcinoma Cell Line.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- A Novel Algorithm for Evaluating Bone Metastatic Potential of Breast Cancer through Morphometry and Computational Mathematics.Diagnostics (Basel, Switzerland) · 2023Article
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- Artificial intelligence applied to breast pathology.Virchows Archiv : an international journal of pathology · 2022Review
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- Cisplatin effect on digital cytomorphometric and bioinformatic tumor cell characteristics in rat ovarian cancer model-a preliminary study.Pharmacological reports : PR · 2021Article
- Introduction to Digital Image Analysis in Whole-slide Imaging: A White Paper from the Digital Pathology Association.Journal of pathology informatics · 2019Review
- Image Analysis-Assisted Nuclear Morphometric Study of Benign and Malignant Breast Aspirates.Journal of microscopy and ultrastructureArticle
- Utility of Image Morphometry in the Atypical Urothelial Cells and High-Grade Urothelial Carcinoma Categories of the Paris System for Reporting Urinary Cytology.Journal of cytologyArticle
- A systematic scoping review on utility of cytomorphometry in the detection of dysplasia in oral potentially malignant disorders.Journal of oral biology and craniofacial researchArticle
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4 authors.
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Abstract
backgroundBreast cancer has emerged as a leading site of cancer among women in India. Fine needle aspiration cytology (FNAC) has been routinely applied in assessment of breast lesions. Cytological evaluation in breast lesions is subjective with a "gray zone" of 6.9-20%. Quantitative evaluation of nuclear size, shape, texture, and density parameters by morphometry can be of diagnostic help in breast tumor.
aimsTo apply nuclear morphometry on cytological breast aspirates and assess its role in differentiating between benign and malignant breast lesions with derivation of suitable cut-off values between the two groups. SETTINGS AND DESIGNS: The present study was a descriptive cross-sectional hospital-based study of nuclear morphometric parameters of benign and malignant cases. MATERIALS AND
methodsThe study included 50 benign breast disease (BBD), 8 atypical ductal hyperplasia (ADH), and 64 carcinoma cases. Image analysis was performed on Papanicolaou-stained FNAC slides by Nikon Imaging Software (NIS)-Elements Advanced Research software (Version 4.00). Nuclear morphometric parameters analyzed included 5 nuclear size, 2 shape, 4 texture, and 2 density parameters.
resultsNuclear morphometry could differentiate between benign and malignant aspirates with a gradually increasing nuclear size parameters from BBD to ADH to carcinoma. Cut-off values of 31.93 μm
conclusionNuclear morphometry is a highly objective tool that could be used to supplement FNAC in differentiating benign from malignant lesions, with an important role in cases with diagnostic dilemma.
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