Evidence map›Paper›PMID 28181998›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2017

Zinc protoporphyrin/heme ratio as parameter of iron status in moderately preterm infants: natural course and associations in the first 4 months.

C G de Waal, L Uijterschout, M Abbink, B Boersma, P Vos, W W Rövekamp, F Hudig, M D Akkermans, J B van Goudoever, F Brus

Open access · bronzeAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

C G de WaalDepartment of Pediatrics, Juliana Children's Hospital, HAGA Teaching Hospital, The Hague, The Netherlands.
L UijterschoutDepartment of Pediatrics, Juliana Children's Hospital, HAGA Teaching Hospital, The Hague, The Netherlands.
M AbbinkDepartment of Pediatrics, Medical Center Alkmaar, Alkmaar, The Netherlands.
B BoersmaDepartment of Pediatrics, Medical Center Alkmaar, Alkmaar, The Netherlands.
P VosDepartment of Pediatrics, Medical Center Haaglanden, The Hague, The Netherlands.
W W RövekampDepartment of Pediatrics, Juliana Children's Hospital, HAGA Teaching Hospital, The Hague, The Netherlands.
F HudigDepartment of Clinical Chemistry, LabWest, HAGA Teaching Hospital, The Hague, the Netherlands.
M D AkkermansDepartment of Pediatrics, Juliana Children's Hospital, HAGA Teaching Hospital, The Hague, The Netherlands.
J B van GoudoeverDepartment of Pediatrics, Emma Children's Hospital, Academic Medical Center, Amsterdam, The Netherlands.
F BrusDepartment of Pediatrics, Juliana Children's Hospital, HAGA Teaching Hospital, The Hague, The Netherlands.
Haga Hospital · NLMedisch Centrum Alkmaar · NLAcademic Medical Center · NLEmma Kinderziekenhuis · NLMedisch Centrum Haaglanden · NLOLVG · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine the natural course of zinc protoporphyrin/heme ratio (ZnPP/H) and its role in the detection of iron deficiency (ID) and iron-deficiency anemia (IDA) in the first 4 months of life in moderately preterm infants. STUDY

designZnPP/H was measured at 1 week, 6 weeks and 4 months postnatal age in a prospective cohort of 161 Dutch infants born at a gestational age of 32+0 to 36+6 weeks who did not receive an erythrocyte transfusion or iron supplementation.

resultsZnPP/H levels decreased in the first 6 weeks and increased thereafter. At 4 months postnatal age, ZnPP/H was higher in the 11 (8.5%) infants with IDA (mean (s.d.): 260.8 (16.1)) but not in the 27 (21.3%) infants with ID (mean (s.d.): 177.0 (15.1)) compared with normal infants (mean (s.d.): 157.3 (12.5)).

conclusionIn moderately preterm infants, ZnPP/H can be of additional value to detect infants at risk for IDA due to iron-deficient erythropoiesis at 4 months of age.

Indexed as

Iron DeficienciesAnemia, Iron-DeficiencyFemaleFerritinsGestational AgeHematologic TestsHemeHumansInfantInfant, NewbornInfant, PrematureIronLinear ModelsMaleNetherlandsProspective StudiesFerritinsHemeIronProtoporphyrinszinc protoporphyrin

Identifiers

PMID28181998
OpenAlexW2586318070

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.