Evidence map›Paper›PMID 28181831›Full record

ArticleDrug delivery2017

Basic concepts and recent advances in nanogels as carriers for medical applications.

Iordana Neamtu, Alina Gabriela Rusu, Alina Diaconu, Loredana Elena Nita, Aurica P Chiriac

Abstract read
In one paragraph

Article in Drug delivery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

117 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Advancing brain immunotherapy through functional nanomaterials.Drug delivery and translational research · 2026
    Review
  6. Article
  7. Article
  8. Heteromultivalent Nanogels as Highly Potent Inhibitors of Pseudomonas Aeruginosa.Angewandte Chemie (International ed. in English) · 2025
    Article
  9. Biocompatible Copolymerized Gold Nanoclusters: Anti-Biomimetics (Basel, Switzerland) · 2025
    Article
  10. Article
  11. Review
  12. Review
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  17. Article
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57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Iordana Neamtua " Petru Poni" Institute of Macromolecular Chemistry , Iasi , Romania.
Alina Gabriela Rusua " Petru Poni" Institute of Macromolecular Chemistry , Iasi , Romania.
Alina Diaconua " Petru Poni" Institute of Macromolecular Chemistry , Iasi , Romania.
Loredana Elena Nitaa " Petru Poni" Institute of Macromolecular Chemistry , Iasi , Romania.
Aurica P Chiriaca " Petru Poni" Institute of Macromolecular Chemistry , Iasi , Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanogels in biomedical field are promising and innovative materials as dispersions of hydrogel nanoparticles based on crosslinked polymeric networks that have been called as next generation drug delivery systems due to their relatively high drug encapsulation capacity, uniformity, tunable size, ease of preparation, minimal toxicity, stability in the presence of serum, and stimuli responsiveness. Nanogels show a great potential in chemotherapy, diagnosis, organ targeting and delivery of bioactive substances. The main subjects reviewed in this article concentrates on: (i) Nanogel assimilation in the nanomedicine domain; (ii) Features and advantages of nanogels, the main characteristics, such as: swelling capacity, stimuli sensitivity, the great surface area, functionalization, bioconjugation and encapsulation of bioactive substances, which are taken into account in designing the structures according to the application; some data on the advantages and limitations of the preparation techniques; (iii) Recent progress in nanogels as a carrier of genetic material, protein and vaccine. The majority of the scientific literature presents the multivalency potential of bioconjugated nanogels in various conditions. Today's research focuses over the overcoming of the restrictions imposed by cost, some medical requirements and technological issues, for nanogels' commercial scale production and their integration as a new platform in biomedicine.

Indexed as

Drug CarriersNanomedicineNanoparticlesDrug CompoundingDrug Delivery SystemsGelsParticle SizePolymersSurface PropertiesTechnology, PharmaceuticalDrug CarriersGelsPolymersdrug releasegenetic materialnanocarrierNanogelphysical and chemical cross linkingprotein and vaccine deliveryresponse to external stimuli

Identifiers

PMID28181831
PMCPMC8240973

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.