ArticleThe British journal of radiology2017
Dose escalation study with respiratory-gated carbon-ion scanning radiotherapy using a simultaneous integrated boost for pancreatic cancer: simulation with four-dimensional computed tomography.
Article in The British journal of radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Application of intrahepatic fiducial markers in carbon ion radiotherapy for pancreatic cancer-Achieving higher precision treatment.Journal of applied clinical medical physics · 2026Article
- Clinical Outcomes of Proton Beam Therapy for Unresectable Locally Advanced Pancreatic Cancer: A Single-Center Retrospective Study.Advances in radiation oncology · 2024Article
- Evaluation of the availability of single-position treatment with a rotating gantry and the validity of deformable image registration dose assessment for pancreatic cancer carbon-ion radiotherapy.Journal of applied clinical medical physics · 2024Article
- Comparing different boost concepts and beam configurations for proton therapy of pancreatic cancer.Physics and imaging in radiation oncology · 2024Article
- Real-time deep neural network-based automatic bowel gas segmentation on X-ray images for particle beam treatment.Physical and engineering sciences in medicine · 2023Article
- Optimizing 3DCT image registration for interfractional changes in carbon-ion prostate radiotherapy.Scientific reports · 2023Article
- Robust treatment planning in scanned carbon-ion radiotherapy for pancreatic cancer: Clinical verification using in-room computed tomography images.Frontiers in oncology · 2022Article
- Article
- Who Will Benefit from Charged-Particle Therapy?Cancer research and treatment · 2021Review
- Adaptive planning based on single beam optimization in passive scattering carbon ion radiotherapy for patients with pancreatic cancer.Radiation oncology (London, England) · 2021Article
- Article
- Long-term outcomes of skull base chordoma treated with high-dose carbon-ion radiotherapy.Head & neck · 2020Article
- Heavy charged particles for gastrointestinal cancers.Journal of gastrointestinal oncology · 2020Review
- Review
- Locally Advanced Pancreatic Ductal Adenocarcinoma: Challenges and Progress.OncoTargets and therapy · 2020Review
- Evolution of Carbon Ion Radiotherapy at the National Institute of Radiological Sciences in Japan.Cancers · 2018Review
- Effective radiotherapeutic treatment intensification in patients with pancreatic cancer: higher doses alone, higher RBE or both?Radiation oncology (London, England) · 2017Review
Corrections and comments
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Authors and funding
7 authors.
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Abstract
objectivePancreatic cancer is a difficult to treat disease with a persistently high mortality rate. We evaluated dose distribution simulation with respiratory-gated carbon-ion pencil beam scanning (C-PBS) with a simultaneous integrated boost (SIB) to increase tumour dose, sparing organs at risk (OARs).
methodsUsing four-dimensional CT data of 12 patients, we delineated gross tumour volume and two clinical target volumes (CTVs). To consider beam range intrafractional uncertainty, we calculated field-specific target volumes, from which two planning target volumes (PTVs) were generated. PTV1 would receive a planned dose of 55.2 Gy [relative biological effectiveness (RBE)-weighted absorbed dose] in 12 fractions, and PTV2 would receive an SIB dose up to 67.2 Gy (RBE). Dose assessments were conducted with regard to the targets and OARs.
resultsCTV2 dose covering 95% of the volume (D
conclusionWe quantified dose escalation with respiratory-gated C-PBS using SIB for pancreatic cancer and revealed that OAR dose was not affected to the same degree as the tumour dose. Advances in knowledge: A simulation study on respiratory-gated C-PBS with SIB for pancreatic cancer was performed. The results indicated the feasibility of dose escalation for pancreatic cancer, which should be confirmed in clinical trials.
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