ArticleScientific reports2017
Using information of relatives in genomic prediction to apply effective stratified medicine.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Sharing approaches in predictive genomics across animals, plants and humans.Nature genetics · 2026Review
- Genomic-inferred cross-selection methods for multi-trait improvement in a recurrent selection breeding program.Plant methods · 2024Article
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- Genomic Prediction of Complex Traits, Principles, Overview of Factors Affecting the Reliability of Genomic Prediction, and Algebra of the Reliability.Methods in molecular biology (Clifton, N.J.) · 2022Article
- An integrative analysis of genomic and exposomic data for complex traits and phenotypic prediction.Scientific reports · 2021Article
- GWAS findings improved genomic prediction accuracy of lipid profile traits: Tehran Cardiometabolic Genetic Study.Scientific reports · 2021Article
- Factors affecting accuracy of estimated effective number of chromosome segments for numerically small breeds.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2021Article
- Genome-wide fine-mapping identifies pleiotropic and functional variants that predict many traits across global cattle populations.Nature communications · 2021Article
- Psychiatric Polygenic Risk Scores as Predictor for Attention Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in a Clinical Child and Adolescent Sample.Behavior genetics · 2020Article
- Efficient polygenic risk scores for biobank scale data by exploiting phenotypes from inferred relatives.Nature communications · 2020Article
- A deterministic equation to predict the accuracy of multi-population genomic prediction with multiple genomic relationship matrices.Genetics, selection, evolution : GSE · 2020Article
- Familial Influences on Neuroticism and Education in the UK Biobank.Behavior genetics · 2020Article
- Impute.me: An Open-Source, Non-profit Tool for Using Data From Direct-to-Consumer Genetic Testing to Calculate and Interpret Polygenic Risk Scores.Frontiers in genetics · 2020Article
- Comparison of genomic predictions for carcass and reproduction traits in Berkshire, Duroc and Yorkshire populations in Korea.Asian-Australasian journal of animal sciences · 2019Article
- Whole-genome mapping of quantitative trait loci and accuracy of genomic predictions for resistance to columnaris disease in two rainbow trout breeding populations.Genetics, selection, evolution : GSE · 2019Article
- Complex Trait Prediction from Genome Data: Contrasting EBV in Livestock to PRS in Humans: Genomic Prediction.Genetics · 2019Review
- Harnessing genomic information for livestock improvement.Nature reviews. Genetics · 2019Review
- Whole Genome Linkage Disequilibrium and Effective Population Size in a Coho Salmon (Frontiers in genetics · 2019Article
- Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood.American journal of human genetics · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Genomic prediction shows promise for personalised medicine in which diagnosis and treatment are tailored to individuals based on their genetic profiles for complex diseases. We present a theoretical framework to demonstrate that prediction accuracy can be improved by targeting more informative individuals in the data set used to generate the predictors ("discovery sample") to include those with genetically close relationships with the subjects put forward for risk prediction. Increase of prediction accuracy from closer relationships is achieved under an additive model and does not rely on any family or interaction effects. Using theory, simulations and real data analyses, we show that the predictive accuracy or the area under the receiver operating characteristic curve (AUC) increased exponentially with decreasing effective size (N
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.