Evidence map›Paper›PMID 28181561›Full record

ArticleScientific reports2017

Peripheral sensory neuron injury contributes to neuropathic pain in experimental autoimmune encephalomyelitis.

I-Ching Wang, Chen-Yen Chung, Fang Liao, Chih-Cheng Chen, Cheng-Han Lee

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Protection From Demyelination by the Novel Adenosine Dual AJournal of cellular and molecular medicine · 2025
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  8. Acid-Sensing Ion Channels and Mechanosensation.International journal of molecular sciences · 2021
    Review
  9. Article
  10. DEG/ENaC Ion Channels in the Function of the Nervous System: From Worm to Man.Advances in experimental medicine and biology · 2021
    Article
  11. Article
  12. Review
  13. Article
  14. Regulatory T Cells and Their Derived Cytokine, Interleukin-35, Reduce Pain in Experimental Autoimmune Encephalomyelitis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Article
  15. Review
  16. Reduced Microglial Activity and Enhanced Glutamate Transmission in the Basolateral Amygdala in Early CNS Autoimmunity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018
    Article
  17. Involvement of advillin in somatosensory neuron subtype-specific axon regeneration and neuropathic pain.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

I-Ching WangInstitute of Biomedical Sciences, Academia Sinica, 128, Sec. 2, Academia Rd., Taiwan.
Chen-Yen ChungInstitute of Biomedical Sciences, Academia Sinica, 128, Sec. 2, Academia Rd., Taiwan.
Fang LiaoInstitute of Biomedical Sciences, Academia Sinica, 128, Sec. 2, Academia Rd., Taiwan.
Chih-Cheng ChenInstitute of Biomedical Sciences, Academia Sinica, 128, Sec. 2, Academia Rd., Taiwan.
Cheng-Han LeeInstitute of Biomedical Sciences, Academia Sinica, 128, Sec. 2, Academia Rd., Taiwan.
Institute of Biomedical Sciences, Academia Sinica · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis (MS)-induced neuropathic pain deteriorates quality of life in patients but is often refractory to treatment. In experimental autoimmune encephalomyelitis (EAE), a rodent model of MS, animals develop neuropathy and inflammation-induced tissue acidosis, which suggests the involvement of acid-sensing ion channels (ASICs). Also, peripheral neuropathy is reported in MS patients. However, the involvement of the peripheral nervous system (PNS) in MS neuropathic pain remains elusive. This study investigated the contribution of ASICs and peripheral neuropathy in MS-induced neuropathic pain. Elicited pain levels were as high in Asic1a

Indexed as

Acid Sensing Ion ChannelsAnalgesicsAnimalsDemyelinating DiseasesEncephalomyelitis, Autoimmune, ExperimentalGanglia, SpinalGray MatterHyperalgesiaLumbar VertebraeMice, KnockoutMicrogliaMotor ActivityMyelin SheathNeuralgiaPeptidesPeripheral Nervous SystemAcid Sensing Ion ChannelsAnalgesicsPeptidesPregabalin

Identifiers

PMID28181561
PMCPMC5299449
OpenAlexW2587240128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.