Evidence map›Paper›PMID 28181494›Full record

ArticleNature communications2017

Microenvironment-derived factors driving metastatic plasticity in melanoma.

Isabella S Kim, Silja Heilmann, Emily R Kansler, Yan Zhang, Milena Zimmer, Kajan Ratnakumar, Robert L Bowman, Theresa Simon-Vermot, Myles Fennell, Ralph Garippa and 5 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 146 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Collective migration modes in development, tissue repair and cancer.Nature reviews. Molecular cell biology · 2025
    Review
  6. Ancestry and somatic profile predict acral melanoma origin and prognosis.medRxiv : the preprint server for health sciences · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Dormancy of cutaneous melanoma.Cancer cell international · 2024
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Isabella S KimMemorial Sloan Kettering Cancer Center, Department of Cancer Biology &Genetics, New York, New York 10065, USA.
Silja HeilmannMemorial Sloan Kettering Cancer Center, Department of Computational Biology, New York, New York 10065, USA.
Emily R KanslerMemorial Sloan Kettering Cancer Center, Department of Cancer Biology &Genetics, New York, New York 10065, USA.
Yan ZhangMemorial Sloan Kettering Cancer Center, Department of Cancer Biology &Genetics, New York, New York 10065, USA.
Milena ZimmerMemorial Sloan Kettering Cancer Center, Department of Cancer Biology &Genetics, New York, New York 10065, USA.
Kajan RatnakumarMemorial Sloan Kettering Cancer Center, Department of Cancer Biology &Genetics, New York, New York 10065, USA.
Robert L BowmanMemorial Sloan Kettering Cancer Center, Department of Cancer Biology &Genetics, New York, New York 10065, USA.
Theresa Simon-VermotMemorial Sloan Kettering Cancer Center, Department of Cancer Biology &Genetics, New York, New York 10065, USA.
Myles FennellMemorial Sloan Kettering Cancer Center, Department of Cancer Biology &Genetics, New York, New York 10065, USA.
Ralph GarippaMemorial Sloan Kettering Cancer Center, Department of Cancer Biology &Genetics, New York, New York 10065, USA.
Liang LuMedical College of Georgia, Augusta, Georgia 30912, USA.
William LeeMemorial Sloan Kettering Cancer Center, Department of Computational Biology, New York, New York 10065, USA.
Travis HollmannMemorial Sloan Kettering Cancer Center, Department of Pathology, New York, New York 10065, USA.
Joao B XavierMemorial Sloan Kettering Cancer Center, Department of Computational Biology, New York, New York 10065, USA.
Richard M WhiteMemorial Sloan Kettering Cancer Center, Department of Cancer Biology &Genetics, New York, New York 10065, USA.ORCID 0000-0001-9099-9169
Memorial Sloan Kettering Cancer Center · USAugusta University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Evolutionary dynamics of melanoma metastasisDP2CA186572 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI WHITE, RICHARD MARK · 2013 to 2013
$2.7M
The role of melanocyte precursors in zebrafish pigmentation disordersK08AR055368 · NIAMS · SLOAN-KETTERING INST CAN RESEARCH · PI WHITE, RICHARD MARK · 2009 to 2013
$635k
NCI NIH HHS DP2 CA186572NCI NIH HHS P30 CA008748NIAMS NIH HHS K08 AR055368
6 · The paper itself

Abstract

Cellular plasticity is a state in which cancer cells exist along a reversible phenotypic spectrum, and underlies key traits such as drug resistance and metastasis. Melanoma plasticity is linked to phenotype switching, where the microenvironment induces switches between invasive/MITF

Indexed as

Cell PlasticityTumor MicroenvironmentAnimalsCell DifferentiationCell ProliferationCRISPR-Cas SystemsGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMelanomaModels, BiologicalNeoplasm MetastasisPhenotypeZebrafishZebrafish ProteinsZebrafish Proteins

Identifiers

PMID28181494
PMCPMC5309794
OpenAlexW2586357858

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.