ArticleClinical & experimental ophthalmology2017
Risk factors for radiation-induced optic neuropathy: a case-control study.
Article in Clinical & experimental ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Dose-Related Visual Outcomes in the Treatment of Choroidal Melanoma with Stereotactic Radiotherapy.Ocular oncology and pathology · 2024Article
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- Human Umbilical Cord Blood-Derived CD133Frontiers in cell and developmental biology · 2022Article
- Peripapillary Neuroendocrine Carcinoma Metastasis: A Novel Approach to Treatment.Ocular oncology and pathology · 2021Article
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- Loosening Neuro-Optic Structures Dosimetric Constraints Provides High 5-Year Local Recurrence-Free Survival With Acceptable Toxicity in T4 Nasopharyngeal Carcinoma Patients Treated With Intensity-Modulated Radiotherapy.Frontiers in oncology · 2021Article
- Radiation-Induced Optic Neuropathy: Literature Review.Neuro-ophthalmology (Aeolus Press) · 2021Review
- Phase I dose-escalation trial of S-1 combined with carbon-ion radiotherapy for sinonasal squamous cell carcinoma.Journal of radiation research · 2020Article
- Radiation-Induced Optical Coherence Tomography Angiography Retinal Alterations in Patients With Nasopharyngeal Carcinoma.Frontiers in medicine · 2020Article
- Predictors of the therapeutic effect of corticosteroids on radiation-induced optic neuropathy following nasopharyngeal carcinoma.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Article
- Imaging findings in radiation therapy complications of the central nervous system.Japanese journal of radiology · 2018Review
- Contour Variability in Thyroid Eye Disease with Compressive Optic Neuropathy Treated with Radiation Therapy.Advances in radiation oncologyArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
importanceIdentifying risk factors for radiation-induced optic neuropathy (RION) could promote a more conservative approach to radiation treatment planning in vulnerable patients.
backgroundThis study explored possible factors beyond radiation dose associated with the development of RION after external beam radiation therapy.
designThis was a retrospective case-control study conducted at a university hospital tertiary care center.
participantsCases (n = 14) meeting criteria for a diagnosis of RION by neuro-ophthalmologic exam were identified from a single-centre neuro-ophthalmology database. Controls (n = 31) without RION were selected from a single-centre radiation oncology database.
methodsControls were matched to cases based upon maximum radiation dose to the optic apparatus. Patient characteristics and treatment parameters were interrogated by univariate analysis for attributes predisposing to RION.
main outcome measuresThe primary parameter was a significant association of patient characteristics or treatment parameters with RION.
resultsControlling for radiation dosage, no significant associations for alternative risk factors were identified. CONCLUSIONS AND RELEVANCE: These results support the literature suggesting that the primary risk factor for developing RION is radiation dosage and that additional patient-related and tumour-related risk factors may play only a minor role.
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