ArticleDevelopmental psychobiology2017
The development of repetitive motor behaviors in deer mice: Effects of environmental enrichment, repeated testing, and differential mediation by indirect basal ganglia pathway activation.
Article in Developmental psychobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bored at home?-A systematic review on the effect of environmental enrichment on the welfare of laboratory rats and mice.Frontiers in veterinary science · 2022Pooled it
- Anticipatory Behavior and Enrichment: Insights into Assessing and Managing Harbor Seal (Animals : an open access journal from MDPI · 2025Article
- Correlation of repetitive behaviors in deer mice with striatal mRNA expression of endogenous opioids and mu, delta, kappa, and dopamine receptors: A preliminary report.Neuroscience · 2025Article
- Article
- Environmental enrichment reduces restricted repetitive behavior by altering gray matter microstructure.PloS one · 2024Article
- Modulation of striatal glutamatergic, dopaminergic and cholinergic neurotransmission pathways concomitant with motor disturbance in rats with kaolin-induced hydrocephalus.Fluids and barriers of the CNS · 2022Article
- The Role of the Cerebellum in Repetitive Behavior Across Species: Childhood Stereotypies and Deer Mice.Cerebellum (London, England) · 2022Article
- A Multi-Target and Multi-Channel Mechanism of Action for Jiawei Yinhuo Tang in the Treatment of Social Communication Disorders in Autism: Network Pharmacology and Molecular Docking Studies.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Neural Mechanisms Underlying Repetitive Behaviors in Rodent Models of Autism Spectrum Disorders.Frontiers in cellular neuroscience · 2020Review
- Reduction of repetitive behavior by co-administration of adenosine receptor agonists in C58 mice.Pharmacology, biochemistry, and behavior · 2019Article
- Targeting Dopamine DThe Journal of pharmacology and experimental therapeutics · 2019Article
- Self-injurious behaviours in rhesus macaques: Potential glial mechanisms.Journal of intellectual disability research : JIDR · 2018Article
- Subthalamic nucleus pathology contributes to repetitive behavior expression and is reversed by environmental enrichment.Genes, brain, and behavior · 2018Article
- Autistic traits in epilepsy models: Why, when and how?Epilepsy research · 2018Review
- Behavioral and neuroanatomical approaches in models of neurodevelopmental disorders: opportunities for translation.Current opinion in neurology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Little is known about the mechanisms mediating the development of repetitive behaviors in human or animals. Deer mice reared with environmental enrichment (EE) exhibit fewer repetitive behaviors and greater indirect basal ganglia pathway activation as adults than those reared in standard cages. The developmental progression of these behavioral and neural circuitry changes has not been characterized. We assessed the development of repetitive behavior in deer mice using both a longitudinal and cohort design. Repeated testing negated the expected effect of EE, but cohort analyses showed that progression of repetitive behavior was arrested after 1 week of EE and differed significantly from controls after 3 weeks. Moreover, EE reductions in repetitive behavior were associated with increasing activation of indirect pathway nuclei in males across adolescence, but not females. These findings provide the first assessment of developmental trajectories within EE and support indirect pathway mediation of repetitive behavior in male deer mice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.