Evidence map›Paper›PMID 28181171›Full record

ArticleNeurotoxicity research2017

Neutrophil-To-Lymphocyte Ratio Predicts 3-Month Outcome of Acute Ischemic Stroke.

Sen Qun, Yan Tang, Jing Sun, Zhaoxia Liu, Juncang Wu, Ji Zhang, Jidong Guo, Zhiqiang Xu, Dan Zhang, Zhengxu Chen and 3 more

Abstract read
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In one paragraph

Article in Neurotoxicity research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 8 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 8 syntheses or guidelines pooled it, 107 citations in OpenAlex.

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  16. Optimal time point for neutrophil-to-lymphocyte ratio to predict stroke-associated pneumonia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Sen QunDepartment of Neurology, the Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, Jiangsu, China.
Yan TangDepartment of Neurology, the Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, Jiangsu, China.
Jing SunDepartment of Neurology, the Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, Jiangsu, China.
Zhaoxia LiuDepartment of Neurology, the Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, Jiangsu, China.
Juncang WuDepartment of Neurology, the Hefei Affiliated Hospital of Anhui Medical University, 246 Heping road, Hefei, Anhui, China.
Ji ZhangDepartment of Neurology, the Hefei Affiliated Hospital of Anhui Medical University, 246 Heping road, Hefei, Anhui, China.
Jidong GuoDepartment of Psychiatry, the Affiliated Guangji Hospital of Soochow University, Suzhou, China.
Zhiqiang XuDepartment of Neurology, the Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, Jiangsu, China.
Dan ZhangDepartment of Neurology, the Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, Jiangsu, China.
Zhengxu ChenDepartment of Neurology, the Hefei Affiliated Hospital of Anhui Medical University, 246 Heping road, Hefei, Anhui, China.
Fuyong HuDepartment of Neurology, the Hefei Affiliated Hospital of Anhui Medical University, 246 Heping road, Hefei, Anhui, China.
Xingshun XuDepartment of Neurology, the Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, Jiangsu, China. Xingshunxu@suda.edu.cn.
Wei GeDepartment of Neurology, the Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, Jiangsu, China. Gw1003@163.com.
Soochow University · CNAnhui Medical University · CNSecond Affiliated Hospital of Soochow University · CNXuzhou Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing evidences have demonstrated that inflammation is involved in the mechanisms of acute ischemic stroke (AIS). As an important and easy-to-measure inflammatory marker, neutrophil-to-lymphocyte ratio (NLR) shows a high association with mortality in patients with stroke in recent studies. In this study, we evaluated the prognostic role of NLR in patients with AIS. One hundred forty-three patients with AIS were enrolled. Clinical data were collected and the NLR was calculated from the admission blood work. The patients were followed up for 3 months after stroke onset. The occurrence of death and the major disability at 3 months after onset were end points in this study. Modified Rankin Scale score ≥3 was considered as poor outcome. In this study, 75 patients (52%) had poor outcome. We used binary logistic regression model to evaluate risk factor for poor outcome of AIS and found that the NLR was independently associated with the poor outcome of 3 months (P < 0.001). The optimal cutoff value for NLR as a predictor for 3-month outcome was 2.995. Therefore, in our study, high NLRs inversely predicted 3-month outcome in patients with AIS.

Indexed as

LymphocytesNeutrophilsPredictive Value of TestsAgedFemaleHumansLogistic ModelsMalePrognosisRisk FactorsSeverity of Illness IndexStroke3-month outcomeAcute ischemic strokeNeutrophil-to-lymphocyte ratioPatients

Identifiers

PMID28181171
OpenAlexW2587351816

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.