Evidence map›Paper›PMID 28181143›Full record

ReviewEndocrine2017

The complex interplay among hepatocytes and immune cells at the crossroad between inflammation and cholesterol metabolism in hyperglycemia.

Maurizio Bifulco, Simona Pisanti, Elena Ciaglia

Abstract readReview
PubMed Publisher
In one paragraph

Review in Endocrine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Maurizio BifulcoDepartment of Medicine and Surgery, University of Salerno, Via Salvatore Allende, Baronissi, 84081, Salerno, Italy. maubiful@unisa.it.
Simona PisantiDepartment of Medicine and Surgery, University of Salerno, Via Salvatore Allende, Baronissi, 84081, Salerno, Italy.
Elena CiagliaDepartment of Medicine and Surgery, University of Salerno, Via Salvatore Allende, Baronissi, 84081, Salerno, Italy.
University of Salerno · IT

Funding

Associazione Italiana per la Ricerca sul Cancro IG13312Associazione Italiana per la Ricerca sul Cancro IG18999Fondazione Umberto Veronesi FUV 1072
6 · The paper itself

Abstract

An intriguing piece of evidence for the inflammatory story of type 2 diabetes has come to the light. A recent study by Okin and colleagues adds new clues to the interplay between cholesterol metabolism and immunity and how it impacts glucose homeostasis in inflammatory conditions. But some questions are a still unsolved conundrum. Here we suggest to better dissect the regulatory mechanism of Mevalonate pathway and to underpin a new causative link between immunometabolic dysregulation and diabetes.

Indexed as

AnimalsCholesterolGlucoseHepatocytesHumansHyperglycemiaInflammationMetabolic Networks and PathwaysMevalonic AcidCholesterolGlucoseMevalonic AcidDiabetesInflammationIsoprenoidsMetabolismMevalonate pathway

Identifiers

PMID28181143
OpenAlexW2587120027

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.