Evidence map›Paper›PMID 28181133›Full record

ArticleMolecular and cellular biochemistry2017

Effects of aerobic exercise training on metabolism of nitric oxide and endothelin-1 in lung parenchyma of rats with pulmonary arterial hypertension.

A Zimmer, R B Teixeira, J H P Bonetto, R Siqueira, C C Carraro, L M Donatti, A Hickmann, I E Litvin, A E G Godoy, A S Araujo and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular and cellular biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 31 citations in OpenAlex.

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  5. Cardioprotection in right heart failure.British journal of pharmacology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

A ZimmerLaboratório de Fisiologia Cardiovascular, Departamento de Fisiologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite 500, Sala 344, CEP 90050170, Porto Alegre, RS, Brazil.
R B TeixeiraLaboratório de Fisiologia Cardiovascular, Departamento de Fisiologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite 500, Sala 344, CEP 90050170, Porto Alegre, RS, Brazil.
J H P BonettoLaboratório de Fisiologia Cardiovascular, Departamento de Fisiologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite 500, Sala 344, CEP 90050170, Porto Alegre, RS, Brazil.
R SiqueiraLaboratório de Fisiologia Cardiovascular, Departamento de Fisiologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite 500, Sala 344, CEP 90050170, Porto Alegre, RS, Brazil.
C C CarraroLaboratório de Fisiologia Cardiovascular, Departamento de Fisiologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite 500, Sala 344, CEP 90050170, Porto Alegre, RS, Brazil.
L M DonattiLaboratório de Fisiologia Cardiovascular, Departamento de Fisiologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite 500, Sala 344, CEP 90050170, Porto Alegre, RS, Brazil.
A HickmannLaboratório de Fisiologia Cardiovascular, Departamento de Fisiologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite 500, Sala 344, CEP 90050170, Porto Alegre, RS, Brazil.
I E LitvinInstituto de Pesquisas Clínicas para Estudos Multicêntricos, da Universidade de Caxias do Sul, Caxias do Sul, RS, Brazil.
A E G GodoyInstituto de Pesquisas Clínicas para Estudos Multicêntricos, da Universidade de Caxias do Sul, Caxias do Sul, RS, Brazil.
A S AraujoLaboratório de Fisiologia Cardiovascular, Departamento de Fisiologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite 500, Sala 344, CEP 90050170, Porto Alegre, RS, Brazil.
R ColomboLaboratório de Farmacologia e Fisiologia, Universidade de Caxias do Sul, Caxias do Sul, RS, Brazil.
Adriane Belló-KleinLaboratório de Fisiologia Cardiovascular, Departamento de Fisiologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite 500, Sala 344, CEP 90050170, Porto Alegre, RS, Brazil. belklein@ufrgs.br.
Universidade Federal do Rio Grande do Sul · BRUniversidade de Caxias do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary arterial hypertension (PAH) is characterized by vasoconstriction and proliferative obstruction of pulmonary vessels, which promotes a progressive increase in pulmonary vascular resistance (PVR). The effect of exercise training on oxidative stress, metabolism, and markers of nitric oxide (NO) and endothelin-1 (ET-1) was analyzed in the lung tissue of rats with PAH induced by monocrotaline (MCT).Twenty-four Wistar rats were divided into four groups (5-7 animals): sedentary control (SC), sedentary MCT (SM), trained control (TC), and trained MCT (TM). The TC and TM groups participated in a treadmill training protocol (60% VO

Indexed as

AnimalsDisease Models, AnimalEndothelin-1Hypertension, PulmonaryMaleMonocrotalineNitric OxideNitric Oxide Synthase Type IIINitritesParenchymal TissuePhysical Conditioning, AnimalRatsRats, WistarVascular ResistanceEndothelin-1MonocrotalineNitric OxideNitric Oxide Synthase Type IIINitritesNos3 protein, ratAerobic exercise trainingEndothelial dysfunctionMonocrotalinePulmonary arterial hypertension

Identifiers

PMID28181133
OpenAlexW2587066556

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.