Evidence map›Paper›PMID 28181132›Full record

ArticleMolecular and cellular biochemistry2017

Anti-TGFβ-1 receptor inhibitor mediates the efficacy of the human umbilical cord mesenchymal stem cells against liver fibrosis through TGFβ-1/Smad pathway.

Ji Xuan, Wang Feng, Zheng-Tao An, Jian Yang, Hua-Bing Xu, Jing Li, Zhi-Fei Zhao, Wei Wen

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular and cellular biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
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  6. Immunomodulatory Effect ofJournal of healthcare engineering · 2022
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  18. Mesenchymal stem cells prolong the survival of orthotopic liver transplants by regulating the expression of TGF-β1.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2018
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ji XuanBayi Hospital Affiliated Nanjing University of Chinese Medicine, No. 34 Yang Gong Jing 34 District, Nanjing, 210002, People's Republic of China.
Wang FengBayi Hospital Affiliated Nanjing University of Chinese Medicine, No. 34 Yang Gong Jing 34 District, Nanjing, 210002, People's Republic of China.
Zheng-Tao AnBayi Hospital Affiliated Nanjing University of Chinese Medicine, No. 34 Yang Gong Jing 34 District, Nanjing, 210002, People's Republic of China.
Jian YangBayi Hospital Affiliated Nanjing University of Chinese Medicine, No. 34 Yang Gong Jing 34 District, Nanjing, 210002, People's Republic of China.
Hua-Bing XuBayi Hospital Affiliated Nanjing University of Chinese Medicine, No. 34 Yang Gong Jing 34 District, Nanjing, 210002, People's Republic of China.
Jing LiBayi Hospital Affiliated Nanjing University of Chinese Medicine, No. 34 Yang Gong Jing 34 District, Nanjing, 210002, People's Republic of China.
Zhi-Fei ZhaoBayi Hospital Affiliated Nanjing University of Chinese Medicine, No. 34 Yang Gong Jing 34 District, Nanjing, 210002, People's Republic of China.
Wei WenBayi Hospital Affiliated Nanjing University of Chinese Medicine, No. 34 Yang Gong Jing 34 District, Nanjing, 210002, People's Republic of China. wenweiabc@yeah.net.
81th Hospital of PLA · CNNanjing University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the current investigation was to evaluate the anti-fibrosis potential of human umbilical cord mesenchymal stem cells (hUC-MSCs) and further to explore some of its underlying mechanisms. Hepatic fibrosis mice model was induced by CCl

Indexed as

AnimalsBenzamidesCarbon TetrachlorideCell MovementCell ProliferationCells, CulturedCombined Modality TherapyDioxolesDisease Models, AnimalGene Expression RegulationHumansLiver CirrhosisMesenchymal Stem Cell TransplantationMiceSignal TransductionSmad Proteins4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamideBenzamidesCarbon TetrachlorideDioxolesSmad ProteinsTgfb1 protein, mouseTransforming Growth Factor beta1Human umbilical cord mesenchymal stem cellsLiver fibrosisTGFβ-1/Smad pathwayTransforming growth factor-β1

Identifiers

PMID28181132
OpenAlexW2586952935

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.