ReviewJournal of assisted reproduction and genetics2017
Oxygen tension in embryo culture: does a shift to 2% O
Review in Journal of assisted reproduction and genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03817671 (The Clinical Outcome of Ultra-low Oxygen Tension on Post Thawed Human Blastocyst), which is not on this map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Clinical Outcome of Ultra-low Oxygen Tension on Post Thawed Human Blastocyst
Who cites it
20 citing papers in PubMed.
- Metabolic control of feto-placental development and pregnancy outcomes.Nature reviews. Endocrinology · 2026Review
- Impacts of Oxygen Tension on Developmental Competence of Preimplantation Embryos.Biomolecules · 2026Review
- Oxygen level alters energy metabolism in bovine preimplantation embryos.Scientific reports · 2025Article
- Comparison of the developmental competence of in vitro-produced mouse embryos cultured under 5 versus 2% OJournal of assisted reproduction and genetics · 2024Article
- A Hypoxia-Decidual Macrophage Regulatory Axis in Normal Pregnancy and Spontaneous Miscarriage.International journal of molecular sciences · 2024Review
- Embryos from Prepubertal Hyperglycemic Female Mice Respond Differentially to Oxygen Tension In Vitro.Cells · 2024Article
- Unraveling the Consequences of Oxygen Imbalance on Early Embryo Development: Exploring Mitigation Strategies.Animals : an open access journal from MDPI · 2023Review
- Biphasic oxygen tension promotes the formation of transferable blastocysts in patients without euploid embryos in previous monophasic oxygen cycles.Scientific reports · 2023Article
- Ultralow Oxygen Tension (2%) Is Beneficial for Blastocyst Formation of In Vitro Human Low-Quality Embryo Culture.BioMed research international · 2022Article
- Biphasic (5-2%) oxygen concentration strategy significantly improves the usable blastocyst and cumulative live birth rates in in vitro fertilization.Scientific reports · 2021Observational
- Redox Regulation and Oxidative Stress in Mammalian Oocytes and Embryos DevelopedInternational journal of environmental research and public health · 2021Review
- The Impact of Hypoxia in Early Pregnancy on Placental Cells.International journal of molecular sciences · 2021Review
- Fertility technologies and how to optimize laboratory performance to support the shortening of time to birth of a healthy singleton: a Delphi consensus.Journal of assisted reproduction and genetics · 2021Article
- Dynamic Oxygen Conditions Promote the Translocation of HIF-1BioMed research international · 2021Article
- Pre-Implantation Mouse Embryos Cultured In Vitro under Different Oxygen Concentrations Show Altered Ultrastructures.International journal of environmental research and public health · 2020Article
- Technical Feasibility and Physiological Relevance of Hypoxic Cell Culture Models.Frontiers in endocrinology · 2020Review
- Reduced oxygen concentration during human IVF culture improves embryo utilization and cumulative pregnancy rates per cycle.Human reproduction open · 2020Article
- Oxygen concentration alters mitochondrial structure and function in in vitro fertilized preimplantation mouse embryos.Human reproduction (Oxford, England) · 2019Article
- Using stem cell oxygen physiology to optimize blastocyst culture while minimizing hypoxic stress.Journal of assisted reproduction and genetics · 2017Article
- Reformatting the reproductive tract to accommodate the needs of human ARTs.Journal of assisted reproduction and genetics · 2017Article
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There has been much debate regarding the optimal oxygen tension in clinical embryo culture. The majority of the literature to date has compared 5% oxygen to atmospheric levels (20-21%). While the majority of modern IVF labs have accepted the superiority of 5% oxygen tension, a new debate has emerged regarding whether a further reduction after day 3 of development represents the most physiologic system. This new avenue of research is based on the premise that oxygen tension is in fact lower in the uterus than in the oviduct and that the embryo crosses the uterotubal junction sometime on day 3. While data are currently limited, recent experience with ultra-low oxygen (2%) after day 3 of development suggests that the optimal oxygen tension in embryo culture may depend on the stage of development. This review article will consider the current state of the literature and discuss ongoing efforts at studying ultra-low oxygen tension in extended culture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.