ArticleBiomechanics and modeling in mechanobiology2017
Biomedical implications from a morphoelastic continuum model for the simulation of contracture formation in skin grafts that cover excised burns.
Article in Biomechanics and modeling in mechanobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 24 citations in OpenAlex.
- Biomorphoelasticity alone: limitations in modeling post-burn contraction and hypertrophy without finite strains.Biomechanics and modeling in mechanobiology · 2025Article
- Stability of a two-dimensional biomorphoelastic model for post-burn contraction.Journal of mathematical biology · 2023Article
- Sensitivity of a two-dimensional biomorphoelastic model for post-burn contraction.Biomechanics and modeling in mechanobiology · 2023Article
- A Bayesian finite-element trained machine learning approach for predicting post-burn contraction.Neural computing & applications · 2022Article
- Sensitivity and feasibility of a one-dimensional morphoelastic model for post-burn contraction.Biomechanics and modeling in mechanobiology · 2021Article
- Mechanobiological wound model for improved design and evaluation of collagen dermal replacement scaffolds.Acta biomaterialia · 2021Article
- Stability of a one-dimensional morphoelastic model for post-burn contraction.Journal of mathematical biology · 2021Article
- Uncertainty quantification on a spatial Markov-chain model for the progression of skin cancer.Journal of mathematical biology · 2020Article
- Can Mathematics and Computational Modeling Help Treat Deep Tissue Injuries?Advances in wound care · 2019Article
- Quantitative cell-based model predicts mechanical stress response of growing tumor spheroids over various growth conditions and cell lines.PLoS computational biology · 2019Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
A continuum hypothesis-based model is developed for the simulation of the (long term) contraction of skin grafts that cover excised burns in order to obtain suggestions regarding the ideal length of splinting therapy and when to start with this therapy such that the therapy is effective optimally. Tissue is modeled as an isotropic, heterogeneous, morphoelastic solid. With respect to the constituents of the tissue, we selected the following constituents as primary model components: fibroblasts, myofibroblasts, collagen molecules, and a generic signaling molecule. Good agreement is demonstrated with respect to the evolution over time of the surface area of unmeshed skin grafts that cover excised burns between outcomes of computer simulations obtained in this study and scar assessment data gathered previously in a clinical study. Based on the simulation results, we suggest that the optimal point in time to start with splinting therapy is directly after placement of the skin graft on its recipient bed. Furthermore, we suggest that it is desirable to continue with splinting therapy until the concentration of the signaling molecules in the grafted area has become negligible such that the formation of contractures can be prevented. We conclude this study with a presentation of some alternative ideas on how to diminish the degree of contracture formation that are not based on a mechanical intervention, and a discussion about how the presented model can be adjusted.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.