Evidence map›Paper›PMID 28180945›Full record

SynthesisEuropean journal of clinical pharmacology2017

Effect of magnesium supplementation on lipid profile: a systematic review and meta-analysis of randomized controlled trials.

Luis E Simental-Mendía, Mario Simental-Mendía, Amirhossein Sahebkar, Martha Rodríguez-Morán, Fernando Guerrero-Romero

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European journal of clinical pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Luis E Simental-MendíaBiomedical Research Unit, Mexican Social Security Institute, Canoas 100, Col. Los Angeles, 34067, Durango, Mexico.
Mario Simental-MendíaDepartment of Biochemistry and Molecular Medicine, Faculty of Medicine, Autonomous University of Nuevo León, Monterrey, NL, Mexico.
Amirhossein SahebkarBiotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Martha Rodríguez-MoránBiomedical Research Unit, Mexican Social Security Institute, Canoas 100, Col. Los Angeles, 34067, Durango, Mexico.
Fernando Guerrero-RomeroBiomedical Research Unit, Mexican Social Security Institute, Canoas 100, Col. Los Angeles, 34067, Durango, Mexico. guerrero.romero@gmail.com.
Mexican Social Security Institute · MXUniversidad Autónoma de Nuevo León · MXUniversity of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe performed a meta-analysis of randomized controlled trials (RCTs) in order to evaluate the effect of oral magnesium supplementation on lipid profile of both diabetic and non-diabetic individuals.

methodsPubMed-Medline, SCOPUS, Web of Science, and Google Scholar databases were searched (from inception to February 23, 2016) to identify RCTs evaluating the effect of magnesium on lipid concentrations. A random-effects model and generic inverse variance method were used for quantitative data synthesis. Sensitivity analysis was conducted using the leave-one-out method. A weighted random-effects meta-regression was performed to evaluate the impact of potential confounders on lipid concentrations.

resultsMagnesium treatment was not found to significantly affect plasma concentrations of any of the lipid indices including total cholesterol (WMD 0.03 mmol/L, 95% CI -0.11, 0.16, p = 0.671), LDL-C (WMD -0.01 mmol/L, 95% CI -0.13, 0.11, p = 0.903), HDL-C (WMD 0.03 mmol/L, 95% CI -0.003, 0.06, p = 0.076), and triglycerides concentrations (WMD -0.10 mmol/L, 95% CI -0.25, 0.04, p = 0.149). In a subgroup analysis comparing studies with and without diabetes, no difference was observed between subgroups in terms of changes in plasma total cholesterol (p = 0.924), LDL-C (p = 0.161), HDL-C (p = 0.822), and triglyceride (p = 0.162) concentrations.

conclusionsResults of the present meta-analysis indicated that magnesium supplementation showed no significant effects on the lipid profile of either diabetic or non-diabetic individuals.

Indexed as

Randomized Controlled Trials as TopicHumansLipidsMagnesiumPublication BiasLipidsMagnesiumCholesterolHDL-cholesterolLipid profileMagnesiumMeta-analysisTriglycerides

Identifiers

PMID28180945
OpenAlexW2587301506

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.