Evidence map›Paper›PMID 28180936›Full record

ArticlePediatric surgery international2017

Fn14 hepatic progenitor cells are associated with liver fibrosis in biliary atresia.

Lulu Zheng, Zhibao Lv, Zhenhua Gong, Qingfeng Sheng, Zhimei Gao, Yuting Zhang, Shenghua Yu, Junmei Zhou, Zhengjun Xi, Xueli Wang

Abstract read
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In one paragraph

Article in Pediatric surgery international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Lulu ZhengDepartment of Pediatric Surgery, Shanghai Children's Hospital, Shanghai Jiao Tong University, No. 355 Luding Road, Shanghai, 200062, China.
Zhibao LvDepartment of Pediatric Surgery, Shanghai Children's Hospital, Shanghai Jiao Tong University, No. 355 Luding Road, Shanghai, 200062, China. lvzhibao1@163.com.
Zhenhua GongDepartment of Pediatric Surgery, Shanghai Children's Hospital, Shanghai Jiao Tong University, No. 355 Luding Road, Shanghai, 200062, China.
Qingfeng ShengDepartment of Pediatric Surgery, Shanghai Children's Hospital, Shanghai Jiao Tong University, No. 355 Luding Road, Shanghai, 200062, China.
Zhimei GaoDepartment of Center Laboratory, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, 200062, China.
Yuting ZhangDepartment of Pediatric Surgery, Shanghai Children's Hospital, Shanghai Jiao Tong University, No. 355 Luding Road, Shanghai, 200062, China.
Shenghua YuDepartment of Pediatric Surgery, Shanghai Children's Hospital, Shanghai Jiao Tong University, No. 355 Luding Road, Shanghai, 200062, China.
Junmei ZhouDepartment of Pediatric Surgery, Shanghai Children's Hospital, Shanghai Jiao Tong University, No. 355 Luding Road, Shanghai, 200062, China.
Zhengjun XiDepartment of Pathology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, 200062, China.
Xueli WangDepartment of Pathology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, 200062, China.
Shanghai Children's Hospital · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe liver in biliary atresia (BA) is characterized by progressing fibrosis which is promoted by unclear reasons. We aimed to understand the factors influencing liver fibrosis. This study hypothesized that HPCs (hepatic progenitor cells) are activated and associated with liver fibrosis in biliary atresia.

methodsLiver samples from biliary atresia patients are as BA group, and the normal liver derived from hepatoblastoma infants during operation are control group. The extent of fibrosis in liver samples was blindly evaluated by two experienced pathologists depending on Ishak system. The BA liver samples were divided into mild liver fibrosis group (grade I-IV, BA

resultsIn mRNA level, Fn14 expression was 21.23 ± 8.3 vs. 1.00 ± 0.17, p = 0.023 < 0.05 and CD133 expression was 6.02 ± 2.16 vs. 1.14 ± 0.75, p = 0.008 < 0.01 between BA group and control group. Fn14 cells co-expressed the progenitor marker CD133 in liver, and activated in BA. Fn14 andα-SMA were co-location in fibrous area in liver. Compared to the control group, Fn14, CD133, and α-SMA protein expression were 2.10 ± 0.53 vs. 0.97 ± 0.2, p = 0.001, 2.23 ± 0.57 vs. 1.00 ± 0.03, p = 0.000, 4.96 ± 2.4 vs. 1.00 ± 0.22, p = 0.001. The Fn14 protein expression was 2.60 ± 0.35 vs. 1.86 ± 0.42, p = 0.012, between BA

conclusionFn14 cells, which co-express the progenitor marker CD133 in liver, are HPCs and activated in BA. Fn14 + HPCs are associated with liver fibrosis in BA.

Indexed as

AdolescentBiliary AtresiaBiomarkersChildChild, PreschoolHumansInfantLiverLiver CirrhosisLiver Function TestsMaleReceptors, Tumor Necrosis FactorStem CellsTWEAK ReceptorBiomarkersReceptors, Tumor Necrosis FactorTNFRSF12A protein, humanTWEAK ReceptorBiliary atresiaFn14+ cellsHPCsLiver fibrosisα-SMA+ cells

Identifiers

PMID28180936
OpenAlexW2587116800

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.