ArticleNeuroImage. Clinical2017
Lateralized occipital degeneration in posterior cortical atrophy predicts visual field deficits.
Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Visual field defects in dementia: A scoping review.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025Pooled it
- Evolution of Visual Field Defects After Occipital Stroke: A Quantitative Analysis.Translational vision science & technology · 2025Article
- Neuroimaging in posterior cortical atrophy: an integrative review for clinicians and radiologists.Frontiers in neurology · 2025Review
- Lobar Microbleeds in the Posterior Cortical Atrophy Syndrome: A Comparison to Typical Alzheimer's Disease.Current neurology and neuroscience reports · 2024Review
- Rehabilitation of visual perception in cortical blindness.Handbook of clinical neurology · 2022Review
- Clinical and radiological profile of posterior cortical atrophy and comparison with a group of typical Alzheimer disease and amnestic mild cognitive impairment.Acta neurologica Belgica · 2021Article
- Benson's Disease or Posterior Cortical Atrophy, Revisited.Journal of Alzheimer's disease : JAD · 2021Review
- Splenial white matter integrity is associated with memory impairments in posterior cortical atrophy.Brain communications · 2021Article
- Linking Multi-Modal MRI to Clinical Measures of Visual Field Loss After Stroke.Frontiers in neuroscience · 2021Article
- The Association Between Perivascular Spaces and Cerebral Blood Flow, Brain Volume, and Cardiovascular Risk.Frontiers in aging neuroscience · 2021Article
- Cerebral regional and network characteristics in asthma patients: a resting-state fMRI study.Frontiers of medicine · 2020Article
- Age at onset reveals different functional connectivity abnormalities in prodromal Alzheimer's disease.Brain imaging and behavior · 2020Article
- Convergence Along the Visual Hierarchy Is Altered in Posterior Cortical Atrophy.Investigative ophthalmology & visual science · 2020Article
- Radiation-Induced Cerebro-Ophthalmic Effects in Humans.Life (Basel, Switzerland) · 2020Review
- Posterior Cortical Atrophy: Characteristics From a Clinical Data Registry.Frontiers in neurology · 2020Article
- Normative cerebral cortical thickness for human visual areas.NeuroImage · 2019Article
- Posterior Cortical Atrophy.Continuum (Minneapolis, Minn.) · 2019Review
- Neural Mechanisms of Visual Dysfunction in Posterior Cortical Atrophy.Frontiers in neurology · 2019Review
- Altered Functional Connectivity and Brain Network Property in Pregnant Women With Cleft Fetuses.Frontiers in psychology · 2019Article
- Visual Dysfunction in Posterior Cortical Atrophy.Frontiers in neurology · 2017Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPosterior cortical atrophy (PCA), the visual variant of Alzheimer's disease, leads to high-level visual deficits such as alexia or agnosia. Visual field deficits have also been identified, but often inconsistently reported. Little is known about the pattern of visual field deficits or the underlying cortical changes leading to this visual loss.
methodsMulti-modal magnetic resonance imaging was used to investigate differences in gray matter volume, cortical thickness, white matter microstructure and functional activity in patients with PCA compared to age-matched controls. Additional analyses investigated hemispheric asymmetries in these metrics according to the visual field most affected by the disease.
resultsAnalysis of structural data indicated considerable loss of gray matter in the occipital and parietal cortices, lateralized to the hemisphere contralateral to the visual loss. This lateralized pattern of gray matter loss was also evident in the hippocampus and parahippocampal gyrus. Diffusion-weighted imaging showed considerable effects of PCA on white matter microstructure in the occipital cortex, and in the corpus callosum. The change in white matter was only lateralized in the occipital lobe, however, with greatest change in the optic radiation contralateral to the visual field deficit. Indeed, there was a significant correlation between the laterality of the optic radiation microstructure and visual field loss.
conclusionsDetailed brain imaging shows that the asymmetric visual field deficits in patients with PCA reflect the pattern of degeneration of both white and gray matter in the occipital lobe. Understanding the nature of both visual field deficits and the neurodegenerative brain changes in PCA may improve diagnosis and understanding of this disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.