SynthesisNeuroImage. Clinical2017
Grey matter alterations in migraine: A systematic review and meta-analysis.
Synthesis in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
106 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- The cerebellum in migraine: a narrative review of anatomical, imaging, and clinical evidence.Frontiers in neurology · 2026Pooled it
- Pooled it
- Human lesions and animal studies link the claustrum to perception, salience, sleep and pain.Brain : a journal of neurology · 2022Pooled it
- Is Migraine Associated to Brain Anatomical Alterations? New Data and Coordinate-Based Meta-analysis.Brain topography · 2021Pooled it
- Invasive Motor Cortex Stimulation Influences Intracerebral Structures in Patients With Neuropathic Pain: An Activation Likelihood Estimation Meta-Analysis of Imaging Data.Neuromodulation : journal of the International Neuromodulation Society · 2020Pooled it
- Alterations in grey matter density and functional connectivity in trigeminal neuropathic pain and trigeminal neuralgia: A systematic review and meta-analysis.NeuroImage. Clinical · 2019Pooled it
- Centrality of prefrontal and motor preparation cortices to Tourette Syndrome revealed by meta-analysis of task-based neuroimaging studies.NeuroImage. Clinical · 2017Pooled it
- Aberrant Spontaneous Low-Frequency Brain Activity in Migraine: A Meta-Analysis of Resting-State fMRI Studies.Journal of neuroimaging : official journal of the American Society of NeuroimagingPooled it
- Differences in gray matter volume in episodic migraine patients with and without prior diagnosis or clinical care: a cross-sectional study.The journal of headache and pain · 2021Trial
- Trial
- Increased activation of the pregenual anterior cingulate cortex to citalopram challenge in migraine: an fMRI study.BMC neurology · 2019Trial
- Impact of chronic migraine attacks and their severity on the endogenous μ-opioid neurotransmission in the limbic system.NeuroImage. Clinical · 2019Trial
- Structural alterations in the superior temporal gyrus associated with depressive symptoms in migraine without aura: a voxel-based morphometry and surface-based morphometry magnetic resonance imaging study.Quantitative imaging in medicine and surgery · 2026Article
- Mapping structural and functional brain networks associated with migraine.The journal of headache and pain · 2026Article
- Non-Invasive Brain Stimulation for Core Symptoms of Chronic Primary Pain: A Meta-Analysis of RCTs.Brain sciences · 2026Review
- Blood-brain barrier integrity and brain entropy in reversible cerebral vasoconstriction syndrome.The journal of headache and pain · 2026Article
- Migraine and menopause as converging factors in brain vulnerability: a hypothesis-driven perspective.The journal of headache and pain · 2026Review
- Sex-specific considerations in migraine therapy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Review
- Concomitant Headache and Its Association With Worse Psychological and Clinical Status in Temporomandibular Disorders.Journal of oral rehabilitation · 2026Article
- Convergent structural brain alterations in chronic pain: a multi-metric individual participant data meta-analysis.Brain communications · 2026Article
46 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo summarize and meta-analyze studies on changes in grey matter (GM) in patients with migraine. We aimed to determine whether there are concordant structural changes in the foci, whether structural changes are concordant with functional changes, and provide further understanding of the anatomy and biology of migraine.
methodsWe searched PubMed and Embase for relevant articles published between January 1985 and November 2015, and examined the references within relevant primary articles. Following exclusion of unsuitable studies, meta-analysis were performed using activation likelihood estimation (ALE).
resultsEight clinical studies were analyzed for structural changes, containing a total of 390 subjects (191 patients and 199 controls). Five functional studies were enrolled, containing 93 patients and 96 controls. ALE showed that the migraineurs had concordant decreases in the GM volume (GMV) in the bilateral inferior frontal gyri, the right precentral gyrus, the left middle frontal gyrus and the left cingulate gyrus. GMV decreases in right claustrum, left cingulated gyrus, right anterior cingulate, amygdala and left parahippocampal gyrus are related to estimated frequency of headache attack
conclusionGM changes in migraineurs may indicate the mechanism of pain processing and associated symptoms. Changes in the frontal gyrus may predispose a person to pain conditions. The limbic regions may be accumulated damage due to the repetitive occurrence of pain-related processes. Increased activation in precentral gyrus and cingulate opposed to GMV decrease might suggest increased effort duo to disorganization of these areas and/or the use of compensatory strategies involving pain processing in migraine. Knowledge of these structural and functional changes may be useful for monitoring disease progression as well as for therapeutic interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.