ArticleNeuroImage. Clinical2017
Disrupted functional connectivity of striatal sub-regions in Bell's palsy patients.
Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Exploratory Study of the Brain Response in Facial Synkinesis after Bell Palsy with Systematic Review and Meta-analysis of the Literature.AJNR. American journal of neuroradiology · 2022Pooled it
- The "Mirror Effect Plus Protocol" for acute Bell's palsy: A randomized controlled trial with 1-year follow-up.Clinical rehabilitation · 2022Trial
- Mind-body exercise improves cognitive function and modulates the function and structure of the hippocampus and anterior cingulate cortex in patients with mild cognitive impairment.NeuroImage. Clinical · 2019Trial
- Enhancing treatment of osteoarthritis knee pain by boosting expectancy: A functional neuroimaging study.NeuroImage. Clinical · 2018Trial
- Alterations in neuroplasticity and functional connectivity of striatal subregions in Bell's palsy patients after acupuncture.Frontiers in neurology · 2025Article
- White matter structural changes before and after microvascular decompression for hemifacial spasm.Brain structure & function · 2024Article
- Abnormal Brain Connectivity in Carpal Tunnel Syndrome Assessed by Graph Theory.Journal of pain research · 2021Article
- Altered Cortical-Striatal Network in Patients With Hemifacial Spasm.Frontiers in human neuroscience · 2021Article
- Shaping the Sensory-Motor Network by Short-Term Unresolvable Sensory-Motor Mismatch.Frontiers in neurology · 2021Article
- Altered brain language network in idiopathic peripheral facial paralysis patients with dysarthria.Annals of translational medicine · 2020Article
- Differences in functional brain alterations driven by right or left facial nerve efferent dysfunction: Evidence from early Bell's palsy.Quantitative imaging in medicine and surgery · 2019Article
- Longitudinal Changes in Functional Connectivity of the Caudate Is Associated With Recovery From Bell's Palsy.Frontiers in aging neuroscience · 2019Article
- Differences in Intrinsic Brain Abnormalities Between Patients With Left- and Right-Sided Long-Term Hearing Impairment.Frontiers in neuroscience · 2019Article
- Altered Brain Fraction Amplitude of Low Frequency Fluctuation at Resting State in Patients With Early Left and Right Bell's Palsy: Do They Have Differences?Frontiers in neuroscience · 2018Article
- The modulation effects of the mind-body and physical exercises on the basolateral amygdala-temporal pole pathway on individuals with knee osteoarthritis.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
The striatum plays an important role in controlling motor function in humans, and its degeneration has the ability to cause severe motor disorders. More specifically, previous studies have demonstrated a disruption in the connectivity of the cortico-striatal loop in patients suffering from motor disorders caused by dopamine dysregulation, such as Parkinson's disease. However, little is known about striatal functional connectivity in patients with motor dysfunction not caused by dopamine dysregulation. In this study, we used early-state Bell's palsy (BP) patients (within 14 days of onset) to investigate how functional connectivity between the striatum and motor cortex is affected by peripheral nerve injury in which the dopamine system remains fully functional. We found a significant increase in the connectivity between the contralateral putamen, and the ipsilateral primary sensory (S1) and motor cortex (M1) in BP patients compared to healthy controls. We also found increased connectivity between the ventral striatum and supplementary motor area (SMA), and the dorsal caudate and medial prefrontal lobe in BP patients compared to healthy controls. Our results demonstrate that the entirety of the striatum is affected following acute peripheral nerve injury, and suggests that this disrupted striatal functional connectivity may reflect a compensatory mechanism for the sensory-motor mismatch caused by BP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.