ArticleIranian Red Crescent medical journal2016
Effect of Saffron (Fan Hong Hua) On the Readiness of The Uterine Cervix In Term Pregnancy: A Placebo-Controlled Randomized Trial.
Article in Iranian Red Crescent medical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Herbal Medicinal Product Use During Pregnancy and the Postnatal Period: A Systematic Review.Obstetrics and gynecology · 2019Pooled it
- Adverse Events of Saffron (Health science reports · 2026Article
- Smooth muscle relaxant activity ofAvicenna journal of phytomedicineArticle
- Comparison of the effects of Date Syrup with Saffron-Honey Syrup on the Progress of Labor in Nulliparous Women: A Single Blind Randomized Clinical Trial.Iranian journal of nursing and midwifery researchArticle
- Saffron and Pregnancy: Cultural Practices, Beliefs, and Safety Evidence: An Integrative Review.Journal of evidence-based integrative medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundReadiness of the cervix is required for successful induction of labor, and there are a number of ways in which this can be achieved.
objectivesThe aim of the present study was to assess whether taking saffron orally could have an effect on the cervical readiness (primary outcome) and some delivery and neonatal outcomes (secondary outcomes) in women in the stage of term pregnancy. PATIENTS AND
methodsIn this double-blind trial, 50 women with a gestational age of 39 to 41 weeks, no indication of cesarean section, a Bishop's score of less than 4, who had plan to have vaginal delivery at Shohada hospital of Bonab, Iran were randomized into two groups receiving three 250mg saffron or placebo pills in 24 hours. The readiness of the cervix was assessed using the Bishop's score. The Mann-Whitney U test was used to compare the scores between the groups.
resultsThere were no significant differences between the groups in terms of the Bishop's score at the baseline (P = 0.792) and 10-12 hours after starting the intervention (P = 0.159). The Bishop's score was significantly higher in the saffron group 20 - 24 hours after the intervention was started (P = 0.029) and just after onset of active uterine contractions (P = 0.003). In the saffron group, there was no cesarean section and 1 meconium staining of the fetus, but 3 and 4, respectively, in the placebo group. There was no statistically significant difference between the groups in terms of the timing of the onset of spontaneous active uterine contractions, the duration of the first and second stages of labor, the need for delivery augmentation, and the first and fifth minutes of neonatal Apgar (P > 0.05). No adverse event was reported in any of the groups.
conclusionsSaffron can increase the readiness of the cervix in term pregnancies. However, the study limitations do not allow for any definite conclusions for its use in clinical practice, and more research is needed to assess its effect on delivery and neonatal outcomes.
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