ArticleIranian endodontic journal2017
Role of CD146 Enrichment in Purification of Stem Cells Derived from Dental Pulp Polyp.
Article in Iranian endodontic journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- The establishment of pulp polyp-derived mesenchymal stem cells with normal karyotype.Journal of dental sciences · 2025Article
- CD146, a therapeutic target involved in cell plasticity.Science China. Life sciences · 2024Review
- Article
- Odontogenic MSC Heterogeneity: Challenges and Opportunities for Regenerative Medicine.Frontiers in physiology · 2022Review
- Human gingival fibroblasts: Isolation, characterization, and evaluation of CD146 expression.Saudi journal of biological sciences · 2021Article
- Regeneration of dentin-pulp complex by using dental pulp stem cells in dog.Dental research journal · 2021Article
- Odontoblast-like Cytodifferentiation of Dental Stem Cells: A Review.Iranian endodontic journal · 2020Review
- Treatment of Periodontal Bone Defects with Stem Cells from Inflammatory Dental Pulp Tissues in Miniature Swine.Tissue engineering and regenerative medicine · 2019Article
- CD146 positive human dental pulp stem cells promote regeneration of dentin/pulp-like structures.Human cell · 2018Article
- Purification of Stem Cells from Oral Pyogenic Granuloma Tissue.The open dentistry journal · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHyperplastic pulpitis (pulp polyp) tissues contains cells with stem cell properties similar to that of the dental pulp stem cells (DPSCs). It has also been shown that CD146 enrichment can homogenize the cultures of DPSCs and enhance the colony forming potentials of their cultures. This study determines whether CD146 enrichment can help purifying the stem cells from heterogeneous cultures of the pulp polyp derived stem cells (PPSCs). METHODS AND MATERIALS: Healthy dental pulps and pulp polyp tissues were enzymatically digested and the harvested single cells were sorted according to the presence of CD146 marker. The sorted cells were seeded directly for colony forming unit (CFU) assays of the negative and positive portions. Flowcytometric antigen panel and differentiation assays were used to see if these cells conform with mesenchymal stems cells (MSCs) definition. Differences between the between groups was assessed using independent t-test. The level of significance was set at 0.05.
resultsNormal pulp tissue derived cells formed higher colonies (42.5±16.8 per 10
conclusionThe entire CFU of PPSCs were formed within CD146 enriched portion. It seems that CD146 enrichment may reduce the number of possible fibroblasts of the pulp polyps and may further homogenize the culture of the PPSCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.