ReviewDialogues in clinical neuroscience2016
Sex differences in the psychopharmacological treatment of depression.
Review in Dialogues in clinical neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 152 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
152 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Predicting treatment outcomes in major depressive disorder using brain magnetic resonance imaging: a meta-analysis.Molecular psychiatry · 2025Pooled it
- Effects of exercise on depression and anxiety in postmenopausal women: a pairwise and network meta-analysis of randomized controlled trials.BMC public health · 2024Pooled it
- Endocannabinoid levels in female-sexed individuals with diagnosed depression: a systematic review.BMC women's health · 2024Pooled it
- A sum of its parts: A systematic review evaluating biopsychosocial and behavioral determinants of perinatal depression.PloS one · 2024Pooled it
- Depression and obesity among females, are sex specificities considered?Archives of women's mental health · 2021Pooled it
- Sex differences in depressive symptoms and tolerability after treatment with selective serotonin reuptake inhibitor antidepressants: Secondary analyses of the GENPOD trial.Journal of psychopharmacology (Oxford, England) · 2021Trial
- Modulation of premotor cortex response to sequence motor learning during escitalopram intake.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Trial
- Sex-based Differences in the Efficacy and Tolerability of Selective Serotonin Reuptake Inhibitors in Adults with Major Depressive Disorder: A Systematic Review and Meta-analysis.Indian journal of psychological medicine · 2026Review
- Women's musculoskeletal health: insights from the 2024 National Academies of Sciences, Engineering, and Medicine report on chronic conditions.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Review
- Top five Alzheimer Disease trial eligibility criteria favor men compared to women in a clinic-based cohort.The journal of prevention of Alzheimer's disease · 2026Observational
- Sex differences in placebo and antidepressant response to intranasal esketamine for treatment-resistant depression.Molecular psychiatry · 2026Article
- Post stress sensory contact with a male mouse is associated with altered social behavior in a female vicarious social defeat stress model.Experimental animals · 2026Article
- Preliminary Evidence for Sex Differences in CYP2C19 Metabolic Capacity During Psychotropic Drug Treatment.Genes · 2026Article
- Physiological Mechanisms in Pregnancy and Their Relevance to the Clinical Management of Perinatal Mental Illness.Journal of clinical medicine · 2026Review
- Impact of sex chromosomes and gonad type in stress susceptibility in corticostriatal brain regions.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Associations between anxiety, somatic pain and sleep disturbances in major depressive disorder and chronic pain: A cross-sectional study with gender-specific insights.General psychiatry · 2026Article
- Alignment between physician and patient perceptions of antidepressant treatment outcomes in routine clinical practice.Scientific reports · 2026Observational
- Anterior Cingulate Cortex Reactivity to Social Stimuli Marks Individual Differences to Peer Victimization on Internalizing Symptoms in Adolescence.JAACAP open · 2026Article
- Sex Differences in Psychotropic Drug Exposure and Safety: A Systematic Review Toward Personalized Dosing Strategies.Journal of personalized medicine · 2026Review
- Quetiapine ameliorates sensorimotor gating, recognition memory, and neuroendocrine plasticity in chronic stress-induced female rats.Metabolic brain disease · 2026Article
92 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although a number of studies have observed that females respond better to serotonergic antidepressants than males and that postmenopausal females have a diminished response to antidepressants compared with younger females, there are also studies that conflict with both of these findings, making any generalizations regarding sex differences difficult to make. Sex variance in antidepressant efficacy and pharmacokinetics profiles have been attributed to sex-based physiological differences, behavioral differences, related disorders, and sex-specific conditions, including pregnancy and menopause. This paper will review the history and current research on sex effects of antidepressant treatment.
Indexed as
Identifiers
28179816PMC5286730What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.