ReviewDialogues in clinical neuroscience2016
Sex differences in the effects of androgens acting in the central nervous system on metabolism.
Review in Dialogues in clinical neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 72 citations in OpenAlex.
- Functional Segregation of Pancreatic Microcirculation Reveals Sex-Dependent Microhemodynamic Signatures.Comprehensive Physiology · 2026Article
- Single-Cell Analysis of Sex and Gender Differences in the Human Brain During Development and Disease.Cellular and molecular neurobiology · 2025Article
- In-utero exposure to real-life environmental chemicals disrupts gene expression within the hypothalamo-pituitary-gonadal axis of prepubertal and adult rams.Environmental research · 2025Article
- LHCGR inactivating variants: single center experience and systematic review of phenotype-genotype of 46,XY and 46,XX patients.Endocrine connections · 2024Article
- Sex-Specific Variation in Metabolic Responses to Diet.Nutrients · 2024Review
- Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes.BMC pharmacology & toxicology · 2024Article
- Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes.bioRxiv : the preprint server for biology · 2023Article
- Higher testosterone is associated with open-angle glaucoma in women: a genetic predisposition?Biology of sex differences · 2023Article
- Sex-specific responses in glucose-insulin homeostasis and lipoprotein-lipid components after high-dose supplementation with marine n-3 PUFAs in abdominal obesity: a randomized double-blind crossover study.Frontiers in nutrition · 2023Article
- Mechanism of leptin-NPY on the onset of puberty in male offspring rats after androgen intervention during pregnancy.Frontiers in endocrinology · 2023Article
- Sex differences in autonomic responses to stress: implications for cardiometabolic physiology.American journal of physiology. Endocrinology and metabolism · 2022Review
- Associations between Urinary and Dietary Selenium and Blood Metabolic Parameters in a Healthy Northern Italy Population.Antioxidants (Basel, Switzerland) · 2021Article
- Affective reactivity during adolescence: Associations with age, puberty and testosterone.Cortex; a journal devoted to the study of the nervous system and behavior · 2019Article
- Sex hormones, obesity and type 2 diabetes: is there a link?Endocrine connections · 2019Review
- The association between serum testosterone and insulin resistance: a longitudinal study.Endocrine connections · 2018Article
- SEXUAL DIMORPHISM IN SELENIUM METABOLISM AND SELENOPROTEINS.Free radical biology & medicine · 2018Review
- Multiple Mechanisms Linking Type 2 Diabetes and Alzheimer's Disease: Testosterone as a Modifier.Journal of Alzheimer's disease : JAD · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the most sexually dimorphic aspects of metabolic regulation is the bidirectional modulation of glucose and energy homeostasis by testosterone in males and females. Testosterone deficiency predisposes men to metabolic dysfunction, with excess adiposity, insulin resistance, and type 2 diabetes, whereas androgen excess predisposes women to insulin resistance, adiposity, and type 2 diabetes. This review discusses how testosterone acts in the central nervous system, and especially the hypothalamus, to promote metabolic homeostasis or dysfunction in a sexually dimorphic manner. We compare the organizational actions of testosterone, which program the hypothalamic control of metabolic homeostasis during development, and the activational actions of testosterone, which affect metabolic function after puberty. We also discuss how the metabolic effect of testosterone is centrally mediated via the androgen receptor.
Indexed as
Identifiers
28179813PMC5286727W2900801340What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.