ReviewDialogues in clinical neuroscience2016
Sex-biased cellular signaling: molecular basis for sex differences in neuropsychiatric diseases.
Review in Dialogues in clinical neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 28 citations in OpenAlex.
- TM5441, a PAI-1 inhibitor, attenuates chronic stress-induced anxio-depressive-like behaviors by restoring the hippocampal PAI-1/tPA/BDNF axis.Psychopharmacology · 2026Article
- D[HisPsychopharmacology · 2026Article
- Sex differences in neuromodulatory subcortical systems and their implications for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Sex-dependent locus coeruleus vulnerability in Alzheimer's disease: gut dysbiosis as a driver and probiotic intervention as rescue.Biology of sex differences · 2026Review
- Are there sex differences in oxytocin and vasopressin V1a receptors ligand binding affinities?Pharmacological reports : PR · 2024Article
- Neurobiological Underpinnings of Hyperarousal in Depression: A Comprehensive Review.Brain sciences · 2024Review
- Neurobehavioral sex-related differences in Nf1Biology of sex differences · 2023Article
- Sex-specific mechanisms of tolerance for the cannabinoid agonists CP55,940 and delta-9-tetrahydrocannabinol (ΔPsychopharmacology · 2022Article
- Sex differences in anxiety and depression: circuits and mechanisms.Nature reviews. Neuroscience · 2021Review
- In search of sex-related mediators of affective illness.Biology of sex differences · 2021Review
- Sex Differences in the Control of Social Investigation and Anxiety by Vasopressin Cells of the Paraventricular Nucleus of the Hypothalamus.Neuroendocrinology · 2021Article
- Pituitary Adenylate Cyclase-Activating Polypeptide in Learning and Memory.Frontiers in cellular neuroscience · 2021Review
- Functional networks activated by controllable and uncontrollable stress in male and female rats.Neurobiology of stress · 2020Article
- Anatomically and functionally distinct locus coeruleus efferents mediate opposing effects on anxiety-like behavior.Neurobiology of stress · 2020Article
- Sex Differences in the Neuropeptide Y System and Implications for Stress Related Disorders.Biomolecules · 2020Review
- Article
- Early-life adversity and neurological disease: age-old questions and novel answers.Nature reviews. Neurology · 2019Review
- Targeting opioid dysregulation in depression for the development of novel therapeutics.Pharmacology & therapeutics · 2019Review
- The Effect of MPP+ on the Viability of Primary Cortical Astrocytes Isolated from Female and Male Wistar Rats of Different Ages.Cellular and molecular neurobiology · 2019Article
- Sex-Specific Differences in Redox Homeostasis in Brain Norm and Disease.Journal of molecular neuroscience : MN · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The recognition that there are fundamental biological sex differences that extend beyond those that define sexual behavior and reproductive function has inspired the drive toward inclusion of both sexes in research design. This is supported by an underlying clinical rationale that studying both sexes is necessary to elucidate pathophysiology and develop treatments for the entire population. However, at a more basic level, sex differences, like genetic differences, can be exploited to better understand biology. Here, we discuss how sex differences at the molecular level of cell signaling and protein trafficking are amplified to create a state of vulnerability that under the right conditions can result in symptoms of neuropsychiatry disease. Although this dialogue focuses on the specific example of corticotropin-releasing factor, the potential for analogous sex differences in signaling and/or trafficking of receptors for other neuromodulators has broad biological and therapeutic implications.
Indexed as
Identifiers
28179810PMC5286724W3024461794What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.