Trial reportInternational journal of obesity (2005)2017
Diet-induced weight loss decreases adipose tissue oxygen tension with parallel changes in adipose tissue phenotype and insulin sensitivity in overweight humans.
Trial report in International journal of obesity (2005), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- The impact of hypoxia exposure on glucose homeostasis in metabolically compromised humans: A systematic review.Reviews in endocrine & metabolic disorders · 2021Pooled it
- Six Weeks of Calorie Restriction Improves Body Composition and Lipid Profile in Obese and Overweight Former Athletes.Nutrients · 2019Trial
- Adipose tissue mitochondrial capacity associates with long-term weight loss success.International journal of obesity (2005) · 2018Trial
- Influence of Weight Loss and Weight Regain on Adipose Tissue Inflammation.Arteriosclerosis, thrombosis, and vascular biology · 2025Review
- Effects of a multicomponent intervention on body composition and cardiovascular risk factors in women with obesity- a randomized clinical trial.Journal of diabetes and metabolic disorders · 2025Article
- Metabolic and hormonal effects of an 8 days water only fasting combined with exercise in middle aged men.Scientific reports · 2025Article
- The role of tissue oxygenation in obesity-related cardiometabolic complications.Reviews in endocrine & metabolic disorders · 2025Review
- The effect of calorie restriction on the anthropometric parameters, HOMA-IR index, and lipid profile of female office workers with overweight and obesity: a preliminary study.International journal of occupational medicine and environmental health · 2022Article
- Review
- Mild intermittent hypoxia exposure induces metabolic and molecular adaptations in men with obesity.Molecular metabolism · 2021Article
- Partial pressure of oxygen in adipose tissue and its relationship with fatness in a natural animal model of extreme fat deposition, the grey seal.Physiological reports · 2021Article
- Differential Mitochondrial Gene Expression in Adipose Tissue Following Weight Loss Induced by Diet or Bariatric Surgery.The Journal of clinical endocrinology and metabolism · 2021Article
- The Effects of Mild Intermittent Hypoxia Exposure on the Abdominal Subcutaneous Adipose Tissue Proteome in Overweight and Obese Men: A First-in-Human Randomized, Single-Blind, and Cross-Over Study.Frontiers in physiology · 2021Article
- Oxygenation of adipose tissue: A human perspective.Acta physiologica (Oxford, England) · 2020Review
- Safflower Yellow and Its Main Component HSYA Alleviate Diet-Induced Obesity in Mice: Possible Involvement of the Increased Antioxidant Enzymes in Liver and Adipose Tissue.Frontiers in pharmacology · 2020Article
- Mechanisms of weight regain after weight loss - the role of adipose tissue.Nature reviews. Endocrinology · 2019Review
- Incretin-based therapies for patients with type 1 diabetes: a meta-analysis.Endocrine connections · 2019Article
- Timing of eating in adults across the weight spectrum: Metabolic factors and potential circadian mechanisms.Physiology & behavior · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesAlthough adipose tissue (AT) hypoxia is present in rodent models of obesity, evidence for this in humans is limited. Here, we investigated the effects of diet-induced weight loss (WL) on abdominal subcutaneous AT oxygen tension (pO SUBJECTS/
methodsFifteen overweight and obese individuals underwent a dietary intervention (DI), consisting of a 5-week very-low-calorie diet (VLCD, 500 kcal day
resultsBody weight, body fat percentage and adipocyte size decreased significantly during the DI period. The DI markedly decreased AT pO
conclusionsVLCD-induced WL markedly decreases abdominal subcutaneous AT pO
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.