ArticleHypertension research : official journal of the Japanese Society of Hypertension2017
Hypothalamic-pituitary-adrenal-axis dysregulation and double product increases potentiate ischemic heart disease risk in a Black male cohort: the SABPA study.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- The Bidirectional Relationship Between Myocardial Infarction and Depression: Risk Factors, Mechanisms, and Interventions.Biomedicines · 2025Review
- Association of psychological resilience with all-cause and cause-specific mortality in older adults: a cohort study.BMC public health · 2024Article
- Glucocorticoids associate with cardiometabolic risk factors in black South Africans.Endocrine connections · 2021Article
- Retinal-glia ischemia and inflammation induced by chronic stress: The SABPA study.Brain, behavior, & immunity - health · 2020Article
- Predictors of Obesity among Gut Microbiota Biomarkers in African American Men with and without Diabetes.Microorganisms · 2019Article
- Cardiovascular Disease and Hair Cortisol: a Novel Biomarker of Chronic Stress.Current cardiology reports · 2019Review
- Clinical significance of stress-related increase in blood pressure: current evidence in office and out-of-office settings.Hypertension research : official journal of the Japanese Society of Hypertension · 2018Review
- A primary aldosteronism-like phenotype identified with the aldosterone-to-angiotensin II ratio in black men: the SABPA study.Cardiovascular journal of AfricaArticle
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Emotional distress has been associated with a poorer prognosis in myocardial infarction patients. Elevated adrenocorticotrophic hormone (ACTH), lower cortisol, dehydroepiandrosterone sulfate (DHEAS) and cortisol:DHEAS, as measures of emotional distress, might correlate with silent myocardial ischemia (SMI) and workload. Thus, we assessed the relationship between emotional distress, SMI and double product (systolic blood pressure (SBP) × heart rate). Cross-sectional South African biethnic single-set cohorts (N=378), aged 44.7±9.52 years, were investigated. Depressive symptoms (Patient Health Questionnaire-9), anthropometric, fasting blood, 24-h double product and 24-h 2-lead electrocardiogram (ST-segment depression) values were obtained. Blacks, mostly men, had increased depressive symptoms, hyperglycemia, SMI, double product, SBP hypertension and ACTH but lower cortisol, DHEAS and cortisol:DHEAS than their White counterparts. Black men had the highest combined SBP hypertension and below-median cortisol prevalence, 38%, compared with 5.9-13.8% in the other groups. Their SMI was associated with ACTH and cortisol:DHEAS (adj. R
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