ArticleJournal of atherosclerosis and thrombosis2018
Carotid Plaque Score and Risk of Cardiovascular Mortality in the Oldest Old: Results from the TOOTH Study.
Article in Journal of atherosclerosis and thrombosis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Association of LDL-C/HDL-C ratio with coronary heart disease: A meta-analysis.Indian heart journalPooled it
- Atherogenic index of plasma combined with carotid crouse score predicts coronary artery disease in young and middle-aged adults.Scientific reports · 2025Article
- UltraAIGenomics: Artificial Intelligence-Based Cardiovascular Disease Risk Assessment by Fusion of Ultrasound-Based Radiomics and Genomics Features for Preventive, Personalized and Precision Medicine: A Narrative Review.Reviews in cardiovascular medicine · 2024Review
- A Non-Coronary, Peripheral Arterial Atherosclerotic Disease (Carotid, Renal, Lower Limb) in Elderly Patients-A Review: Part I-Epidemiology, Risk Factors, and Atherosclerosis-Related Diversities in Elderly Patients.Journal of clinical medicine · 2024Review
- Article
- Association between Metabolically Healthy Obesity and Subclinical Atherosclerosis in the Cardiovascular and Metabolic Diseases Etiology Research Center (CMERC) Cohort.Journal of clinical medicine · 2022Article
- Association between rotating night shift work and carotid atherosclerosis among Chinese steelworkers: a cross-sectional survey.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- Association between insomnia and subclinical atherosclerosis among Chinese steelworkers: a cross-sectional survey.Archives of public health = Archives belges de sante publique · 2022Article
- Article
- Low-/high-density lipoprotein cholesterol ratio and carotid plaques in patients with coronary heart disease: a Chinese cohort study.Lipids in health and disease · 2021Article
- Carotid plaque imaging and the risk of atherosclerotic cardiovascular disease.Cardiovascular diagnosis and therapy · 2020Review
- Association of aortic valve calcification with carotid artery lesions and peripheral artery disease in patients with chronic kidney disease: a cross-sectional study.BMC nephrology · 2020Article
- Clinical Impact of Carotid Plaque Score rather than Carotid Intima-Media Thickness on Recurrence of Atherosclerotic Cardiovascular Disease Events.Journal of atherosclerosis and thrombosis · 2020Article
- Carotid Disease and Ageing: A Literature Review on the Pathogenesis of Vascular Senescence in Older Subjects.Current gerontology and geriatrics research · 2020Review
- Association between lipid profiles and presence of carotid plaque.Scientific reports · 2019Article
- A low-cost machine learning-based cardiovascular/stroke risk assessment system: integration of conventional factors with image phenotypes.Cardiovascular diagnosis and therapy · 2019Article
- Subclinical atherosclerosis burden predicts cardiovascular events in individuals with diabetes and chronic kidney disease.Cardiovascular diabetology · 2019Observational
- A Special Report on Changing Trends in Preventive Stroke/Cardiovascular Risk Assessment Via B-Mode Ultrasonography.Current atherosclerosis reports · 2019Review
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimAccumulating evidence suggests that predictability of traditional cardiovascular risk factors declines with advancing age. We investigated whether carotid plaque scores (CPSs) were associated with cardiovascular disease (CVD) death in the oldest old, and whether asymmetrical dimethylarginine (ADMA), a marker of endothelial dysfunction, moderated the association between the CPS and CVD death.
methodsWe conducted a prospective cohort study of Japanese subjects aged ≥85 years without CVD at baseline. We followed this cohort for 6 years to investigate the association of CPS with CVD death via multivariable Cox proportional hazard analysis. We divided participants into three groups according to CPS (no, 0 points; low, 1.2-4.9 points; high, ≥5.0 points). The predictive value of CPS for estimating CVD death risk over CVD risk factors, including ADMA, was examined using C-statistics.
resultsWe analyzed 347 participants (151 men, 196 women; mean age, 87.6 years), of which 135 (38.9%) had no carotid plaque at baseline, and 48 (13.8%) had high CPS. Of the total, 29 (8.4%) participants experienced CVD-related death during the study period. Multivariable analysis revealed a significant association of high CPS with CVD-related mortality relative to no CPS (hazard ratio, 3.90; 95% confidence interval: 1.47-10.39). ADMA was not associated with CVD death, but the significant association between CPS and CVD death was observed only in lower ADMA level. The addition of CPS to other risk factors improved the predictability of CVD death (p=0.032).
conclusionsHigh CPS correlated significantly with a higher CVD death risk in the oldest old with low cardiovascular risk. Ultrasound carotid plaque evaluation might facilitate risk evaluations of CVD death in the very old.
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