ArticleProceedings of the National Academy of Sciences of the United States of America2017
Human and rat gut microbiome composition is maintained following sleep restriction.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 4 of them syntheses that pooled it.
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Who cites it
81 citing papers in PubMed, 4 syntheses or guidelines pooled it, 136 citations in OpenAlex.
- What is the nature of sleep and circadian rhythm health on gastrointestinal microbiota? A systematic review of studies in humans.Sleep medicine reviews · 2026Pooled it
- The Microbiota-Gut-Brain Axis in Metabolic Syndrome and Sleep Disorders: A Systematic Review.Nutrients · 2024Pooled it
- Gut microbiome changes due to sleep disruption in older and younger individuals: a case for sarcopenia?Sleep · 2022Pooled it
- Prevalence of sleep disorder in irritable bowel syndrome: A systematic review with meta-analysis.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationPooled it
- Exploring the relationship between social jetlag with gut microbial composition, diet and cardiometabolic health, in the ZOE PREDICT 1 cohort.European journal of nutrition · 2023Trial
- Extending Sleep Improves Sleep and Stress Measures With Limited Microbiome Shift.Journal of sleep research · 2026Article
- The diversity of factors influencing human digestive microbiota in healthy adults and their interaction: a scoping review.BMC nutrition · 2026Article
- From alpha diversity to zeitgebers: Bacterial gut microbiome associations with sleep and circadian disruption (Part I).Neuroscience and biobehavioral reviews · 2026Review
- Restoring circadian disrupted gut microbial metabolite rhythms with phytochemicals: a new avenue against metabolic disease.Frontiers in microbiology · 2026Review
- Do microbiota rhythms influence cognitive performance? - A narrative review.Frontiers in molecular neuroscience · 2026Review
- Gut microbiome, stress and interventional strategies using hardy animals.Future science OA · 2025Review
- The Gut Microbiota Axis in Social Jetlag: A Novel Framework for Metabolic Dysfunction and Chronotherapeutic Innovation.Medicina (Kaunas, Lithuania) · 2025Review
- Impacts of night shift on medical professionals: a pilot study of brain connectivity and gut microbiota.Frontiers in neuroscience · 2025Article
- Sleep and Sugar: Deciphering the 2003-2023 Research Landscape on Sleep Disorders and Diabetes Mellitus via Bibliometric Study.Journal of multidisciplinary healthcare · 2025Article
- The new science of sleep: From cells to large-scale societies.PLoS biology · 2024Article
- Gut Microbiota Dysbiosis and Sleep Disorders: Culprit in Cardiovascular Diseases.Journal of clinical medicine · 2024Review
- Article
- The impact of plant-rich diets on sleep: a mini-review.Frontiers in nutrition · 2024Review
- Impact of age-related gut microbiota dysbiosis and reduced short-chain fatty acids on the autonomic nervous system and atrial fibrillation in rats.Frontiers in cardiovascular medicine · 2024Article
- Linking Gut Microbiota, Oral Microbiota, and Serum Metabolites in Insomnia Disorder: A Preliminary Study.Nature and science of sleep · 2024Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Insufficient sleep increasingly characterizes modern society, contributing to a host of serious medical problems. Loss of sleep is associated with metabolic diseases such as obesity and diabetes, cardiovascular disorders, and neurological and cognitive impairments. Shifts in gut microbiome composition have also been associated with the same pathologies; therefore, we hypothesized that sleep restriction may perturb the gut microbiome to contribute to a disease state. In this study, we examined the fecal microbiome by using a cross-species approach in both rat and human studies of sleep restriction. We used DNA from hypervariable regions (V1-V2) of 16S bacteria rRNA to define operational taxonomic units (OTUs) of the microbiome. Although the OTU richness of the microbiome is decreased by sleep restriction in rats, major microbial populations are not altered. Only a single OTU, TM7-3a, was found to increase with sleep restriction of rats. In the human microbiome, we find no overt changes in the richness or composition induced by sleep restriction. Together, these results suggest that the microbiome is largely resistant to changes during sleep restriction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.