Evidence map›Paper›PMID 28179565›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

High-resolution imaging of cellular dopamine efflux using a fluorescent nanosensor array.

Sebastian Kruss, Daniel P Salem, Lela Vuković, Barbara Lima, Emma Vander Ende, Edward S Boyden, Michael S Strano

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 221 citations in OpenAlex.

  1. Article
  2. Review
  3. Multimodal Imaging Reveals Rapid Catecholamine Uptake and Release by Neutrophils.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  7. Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  8. Article
  9. Article
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  12. Article
  13. Genetically encoded sensors illuminateIBRO neuroscience reports · 2025
    Article
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  17. Review
  18. Article
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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Sebastian KrussDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
Daniel P SalemDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
Lela VukovićDepartment of Physics, University of Illinois at Urbana-Champaign, Champaign, IL 61801.
Barbara LimaDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
Emma Vander EndeDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
Edward S BoydenMedia Lab, Massachusetts Institute of Technology, Cambridge, MA 02139.
Michael S StranoDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139; strano@mit.edu.
Massachusetts Institute of Technology · USMcGovern Institute for Brain Research · USThe University of Texas at El Paso · US

Funding

WHOLE CELL SIMULATIONP41GM104601 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI TAJKHORSHID, EMAD · 2012 to 2021
$19.0M
NIGMS NIH HHS P41 GM104601
6 · The paper itself

Abstract

Intercellular communication via chemical signaling proceeds with both spatial and temporal components, but analytical tools, such as microfabricated electrodes, have been limited to just a few probes per cell. In this work, we use a nonphotobleaching fluorescent nanosensor array based on single-walled carbon nanotubes (SWCNTs) rendered selective to dopamine to study its release from PC12 neuroprogenitor cells at a resolution exceeding 20,000 sensors per cell. This allows the spatial and temporal dynamics of dopamine release, following K

Indexed as

AnimalsBiosensing TechniquesCell CommunicationCell MembraneDopamineElectrochemical TechniquesElectrodesFluorescenceMicroscopyModels, NeurologicalNanotubes, CarbonNeural Stem CellsPC12 CellsRatsSignal TransductionSingle Molecule ImagingDopamineNanotubes, Carboncarbon nanotubeschemical signalingdopamineimagingsensors

Identifiers

PMID28179565
PMCPMC5338365
OpenAlexW2587677137

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.