ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Individual Differences in Resting Corticospinal Excitability Are Correlated with Reaction Time and GABA Content in Motor Cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 63 citations in OpenAlex.
- Sex-related differences in fractionated reaction time are not related to corticospinal excitability and inhibition.European journal of applied physiology · 2026Article
- Dynamics of cortical excitability in stimulus-response mapping for overt and covert movements is locked to visual stimulus: an LRP-TMS study.Experimental brain research · 2026Article
- Intermittent hypoxia-induced enhancements in corticospinal excitability predict gains in motor learning and metabolic efficiency.Scientific reports · 2025Article
- The effect of time of day on visual reaction time performance in boxers: evaluation in terms of chronotype.Frontiers in physiology · 2025Article
- Intermittent Hypoxia-Induced Enhancements in Corticospinal Excitability Predict Gains in Motor Learning and Metabolic Efficiency.Research square · 2024Article
- Reliability of a method to assess corticomotor excitability of lower limb muscles using a normalized EMG motor thresholding procedure.Scientific reports · 2024Article
- Acute Effects of Sprint Interval Training and Chronic Effects of Polarized Training (Sprint Interval Training, High Intensity Interval Training, and Endurance Training) on Choice Reaction Time in Mountain Bike Cyclists.International journal of environmental research and public health · 2022Article
- The Effects of a Visual Stimuli Training Program on Reaction Time, Cognitive Function, and Fitness in Young Soccer Players.Sensors (Basel, Switzerland) · 2022Article
- Inhibition for gain modulation in the motor system.Experimental brain research · 2022Review
- Article
- Cortical silent period reflects individual differences in action stopping performance.Scientific reports · 2021Article
- Motor adaptation and internal model formation in a robot-mediated forcefield.Psychoradiology · 2021Article
- Relationship between GABA levels and task-dependent cortical excitability in children with attention-deficit/hyperactivity disorder.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021Article
- Dissociable roles of cortical excitation-inhibition balance during patch-leaving versus value-guided decisions.Nature communications · 2021Article
- Human Theta Burst Stimulation Combined with Subsequent Electroacupuncture Increases Corticospinal Excitability.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Conditioning transcranial magnetic stimulation of ventral premotor cortex shortens simple reaction time.Cortex; a journal devoted to the study of the nervous system and behavior · 2019Article
- Longitudinal assessment ofExperimental brain research · 2019Article
- Offline effects of transcranial direct current stimulation on reaction times of lower extremity movements in people after stroke: a pilot cross-over study.Journal of neuroengineering and rehabilitation · 2019Article
- Individual differences in intracortical inhibition predict motor-inhibitory performance.Experimental brain research · 2019Article
- Sensorimotor Oscillatory Phase-Power Interaction Gates Resting Human Corticospinal Output.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Individuals differ in the intrinsic excitability of their corticospinal pathways and, perhaps more generally, their entire nervous system. At present, we have little understanding of the mechanisms underlying these differences and how variation in intrinsic excitability relates to behavior. Here, we examined the relationship between individual differences in intrinsic corticospinal excitability, local cortical GABA levels, and reaction time (RT) in a group of 20 healthy human adults. We measured corticospinal excitability at rest with transcranial magnetic stimulation, local concentrations of basal GABA with magnetic resonance spectroscopy, and RT with a behavioral task. All measurements were repeated in two separate sessions, and tests of reliability confirmed the presence of stable individual differences. There was a negative correlation between corticospinal excitability and RT, such that larger motor-evoked potentials (MEPs) measured at rest were associated with faster RTs. Interestingly, larger MEPs were associated with higher levels of GABA in M1, but not in three other cortical regions. Together, these results suggest that individuals with more excitable corticospinal pathways are faster to initiate planned responses and have higher levels of GABA within M1, possibly to compensate for a more excitable motor system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.