Evidence map›Paper›PMID 28179555›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017

Role of the Excitability Brake Potassium Current I

Alejandro González, Gonzalo Ugarte, Carlos Restrepo, Gaspar Herrera, Ricardo Piña, José Antonio Gómez-Sánchez, María Pertusa, Patricio Orio, Rodolfo Madrid

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 51 citations in OpenAlex.

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  8. Review
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  11. KThe Journal of physiology · 2022
    Article
  12. Article
  13. Studying IndependentThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  14. Constitutive Phosphorylation as a Key Regulator of TRPM8 Channel Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  15. Article
  16. Article
  17. Kv4.3 Channel Dysfunction Contributes to Trigeminal Neuropathic Pain Manifested with Orofacial Cold Hypersensitivity in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  18. AAV-Mediated Combination Gene Therapy for Neuropathic Pain: GAD65, GDNF, and IL-10.Molecular therapy. Methods & clinical development · 2020
    Article
  19. Article
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4 · The record

Corrections and comments

  • Commented on by
    The2017
5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Alejandro GonzálezDepartamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, 9160000 Santiago, Chile.ORCID 0000-0001-7513-2516
Gonzalo UgarteDepartamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, 9160000 Santiago, Chile.
Carlos RestrepoDepartamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, 9160000 Santiago, Chile.
Gaspar HerreraCentro Interdisciplinario de Neurociencia de Valparaíso and Instituto de Neurociencia, Facultad de Ciencias, Universidad de Valparaíso, 2340000 Valparaíso, Chile, and.ORCID 0000-0002-9277-6652
Ricardo PiñaDepartamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, 9160000 Santiago, Chile.
José Antonio Gómez-SánchezUniversity College London, Cell and Biology Department, W1CE 6BT London, United Kingdom.
María PertusaDepartamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, 9160000 Santiago, Chile.
Patricio OrioCentro Interdisciplinario de Neurociencia de Valparaíso and Instituto de Neurociencia, Facultad de Ciencias, Universidad de Valparaíso, 2340000 Valparaíso, Chile, and.ORCID 0000-0003-0332-8098
Rodolfo MadridDepartamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, 9160000 Santiago, Chile, rodolfo.madrid@usach.cl.ORCID 0000-0002-8623-5761
Universidad de Santiago de Chile · CLUniversity of Valparaíso · CLMRC Laboratory for Molecular Cell Biology · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cold allodynia is a common symptom of neuropathic and inflammatory pain following peripheral nerve injury. The mechanisms underlying this disabling sensory alteration are not entirely understood. In primary somatosensory neurons, cold sensitivity is mainly determined by a functional counterbalance between cold-activated TRPM8 channels and Shaker-like Kv1.1-1.2 channels underlying the excitability brake current I

Indexed as

AnimalsCells, CulturedChronic DiseaseCold TemperatureComputer SimulationHyperalgesiaIon Channel GatingMaleMiceMice, Inbred BALB CModels, NeurologicalNociceptorsPeripheral Nerve InjuriesPotassiumTRPM Cation ChannelsPotassiumTRPM8 protein, mouseTRPM Cation Channels4-APKv1 channelsPBMCthermotransductionTRPM8α-DTx

Identifiers

PMID28179555
PMCPMC6596778
OpenAlexW2587605811

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.