Evidence map›Paper›PMID 28179547›Full record

ArticleJournal of the Royal Society, Interface2017

Suppression of epileptic seizures via Anderson localization.

Benjamin J Zhang, Maysamreza Chamanzar, Mohammad-Reza Alam

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Royal Society, Interface, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Benjamin J ZhangDepartment of Mechanical Engineering, University of California, Berkeley, CA 94720, USA.
Maysamreza ChamanzarDepartment of Electrical Engineering and Computer Sciences, University of California, Berkeley, CA 94720, USA.
Mohammad-Reza AlamDepartment of Mechanical Engineering, University of California, Berkeley, CA 94720, USA reza.alam@berkeley.edu.ORCID 0000-0002-9730-0717

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here we show that brain seizures can be effectively suppressed through random modulation of the brain medium. We use an established mesoscale cortical model in the form of a system of coupled stochastic partial differential equations. We show that by temporal and spatial randomization of parameters governing the firing rates of the excitatory and inhibitory neuron populations, seizure waves can be significantly suppressed. We find that the attenuation is the most effective when applied to the mean threshold potential. The proposed technique can serve as a non-invasive paradigm to mitigate epileptic seizures without knowing the location of the epileptic foci.

Indexed as

Models, NeurologicalBrainEpilepsyHumansAnderson localizationepilepsymesoscale cortical modelseizure attenuationseizures

Identifiers

PMID28179547
PMCPMC5332572

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.