Evidence map›Paper›PMID 28179517›Full record

ArticleProceedings. Biological sciences2017

A new developmental mechanism for the separation of the mammalian middle ear ossicles from the jaw.

Daniel J Urban, Neal Anthwal, Zhe-Xi Luo, Jennifer A Maier, Alexa Sadier, Abigail S Tucker, Karen E Sears

Open access · hybridAbstract read
In one paragraph

Article in Proceedings. Biological sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 58 citations in OpenAlex.

  1. Review
  2. Biomechanics of the mandibular middle ear of the cynodontProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Modularity, homology, heterochrony: Gavin de Beer's legacy to the mammalian skull.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  7. Review
  8. Hearing without a tympanic ear.The Journal of experimental biology · 2022
    Review
  9. A new mammal from the Lower Cretaceous Jehol Biota and implications for eutherian evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Article
  10. Mammalian face as an evolutionary novelty.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  11. Article
  12. Article
  13. Making and shaping endochondral and intramembranous bones.Developmental dynamics : an official publication of the American Association of Anatomists · 2021
    Review
  14. Article
  15. Diverse Fate of an Enigmatic Structure: 200 Years of Meckel's Cartilage.Frontiers in cell and developmental biology · 2020
    Review
  16. Article
  17. Article
  18. Review
  19. Evolvability of the vertebrate craniofacial skeleton.Seminars in cell & developmental biology · 2019
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Daniel J UrbanSchool of Integrative Biology, University of Illinois, 505 S Goodwin Avenue, Urbana, IL 61801, USA.
Neal AnthwalDepartment of Craniofacial Development and Stem Cell Biology, King's College London, London, UK.
Zhe-Xi LuoDepartment of Organismal Biology and Anatomy, University of Chicago, Chicago, IL 60637, USA.
Jennifer A MaierSchool of Integrative Biology, University of Illinois, 505 S Goodwin Avenue, Urbana, IL 61801, USA.
Alexa SadierSchool of Integrative Biology, University of Illinois, 505 S Goodwin Avenue, Urbana, IL 61801, USA.
Abigail S TuckerDepartment of Craniofacial Development and Stem Cell Biology, King's College London, London, UK.ORCID 0000-0001-8871-6094
Karen E SearsSchool of Integrative Biology, University of Illinois, 505 S Goodwin Avenue, Urbana, IL 61801, USA ksears2@illinois.edu.ORCID 0000-0001-9744-9602
University of Illinois Urbana-Champaign · USKing's College London · GBUniversity of Chicago · US

Funding

Wellcome Trust 102889/Z/13/Z
6 · The paper itself

Abstract

Multiple mammalian lineages independently evolved a definitive mammalian middle ear (DMME) through breakdown of Meckel's cartilage (MC). However, the cellular and molecular drivers of this evolutionary transition remain unknown for most mammal groups. Here, we identify such drivers in the living marsupial opossum

Indexed as

AnimalsBiological EvolutionEar, MiddleEar OssiclesFossilsJawMammalsMiceMonodelphisProtein Serine-Threonine KinasesReceptors, Transforming Growth Factor betaReceptor, Transforming Growth Factor-beta Type IITransforming Growth Factor betaProtein Serine-Threonine KinasesReceptors, Transforming Growth Factor betaReceptor, Transforming Growth Factor-beta Type IITransforming Growth Factor betaapoptosismarsupialMeckel's cartilageorigin of mammalsTGFB signalling

Identifiers

PMID28179517
PMCPMC5310609
OpenAlexW2587086207

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.