Evidence map›Paper›PMID 28179367›Full record

ArticleGenetics2017

Genomic Rearrangements in

Martha Imprialou, André Kahles, Joshua G Steffen, Edward J Osborne, Xiangchao Gan, Janne Lempe, Amarjit Bhomra, Eric Belfield, Anne Visscher, Robert Greenhalgh and 12 more

Abstract read
In one paragraph

Article in Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Modeling copy number variation in the genomic prediction of maize hybrids.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2019
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Martha ImprialouWellcome Trust Centre for Human Genetics, University of Oxford, OX3 7BN, United Kingdom.
André KahlesDepartment of Computer Science, Swiss Federal Institute of Technology in Zurich, 8092, Switzerland.ORCID 0000-0002-3411-0692
Joshua G SteffenDepartment of Biology, University of Utah, Salt Lake City, Utah 84112-0840.
Edward J OsborneDepartment of Biology, University of Utah, Salt Lake City, Utah 84112-0840.
Xiangchao GanDepartment of Comparative Development and Genetics, Max Planck Institute for Plant Breeding Research, 50829 Köln, Germany.ORCID 0000-0001-6398-5191
Janne LempeDepartment of Comparative Development and Genetics, Max Planck Institute for Plant Breeding Research, 50829 Köln, Germany.
Amarjit BhomraWellcome Trust Centre for Human Genetics, University of Oxford, OX3 7BN, United Kingdom.
Eric BelfieldDepartment of Plant Sciences, University of Oxford, OX1 3RB, United Kingdom.
Anne VisscherDepartment of Plant Sciences, University of Oxford, OX1 3RB, United Kingdom.
Robert GreenhalghDepartment of Biology, University of Utah, Salt Lake City, Utah 84112-0840.
Nicholas P HarberdDepartment of Plant Sciences, University of Oxford, OX1 3RB, United Kingdom.
Richard GoramJohn Innes Centre, Norwich NR4 7UH, United Kingdom.
Jotun HeinDepartment of Statistics, University of Oxford, OX1 3TG, United Kingdom.ORCID 0000-0002-8100-0824
Alexandre Robert-SeilaniantzUMR INRA-Agrocampus Ouest-Université de Rennes 1, 35653 Le Rheu Cedex, France.
Jonathan JonesThe Sainsbury Laboratory, Norwich Research Park, NR4 7UH, United Kingdom.ORCID 0000-0002-4953-261X
Oliver StegleEuropean Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, United Kingdom.ORCID 0000-0002-8818-7193
Paula KoverDepartment of Biology and Biochemistry, University of Bath, BA2 7AY, United Kingdom.
Miltos TsiantisDepartment of Comparative Development and Genetics, Max Planck Institute for Plant Breeding Research, 50829 Köln, Germany.
Magnus NordborgDepartment of Population Genetics, Gregor Mendel Institute of Molecular Plant Biology, 1030 Vienna, Austria.ORCID 0000-0001-7178-9748
Gunnar RätschDepartment of Computer Science, Swiss Federal Institute of Technology in Zurich, 8092, Switzerland.ORCID 0000-0001-5486-8532
Richard M ClarkDepartment of Biology, University of Utah, Salt Lake City, Utah 84112-0840.ORCID 0000-0002-1470-301X
Richard MottUCL Genetics Institute, University College London, WC1 6BT, United Kingdom r.mott@ucl.ac.uk.ORCID 0000-0002-1022-9330

Funding

TRAINING PROGRAM IN GENETICST32GM007464 · NIGMS · UNIVERSITY OF UTAH · PI GRUNWALD, DAVID J., STANFIELD, GILLIAN · 1985 to 2020
$6.1M
Biotechnology and Biological Sciences Research Council BB/F022697/1Biotechnology and Biological Sciences Research Council BB/M003809/1NIGMS NIH HHS T32 GM007464Wellcome TrustWellcome Trust 090532/Z/09/Z
6 · The paper itself

Abstract

To understand the population genetics of structural variants and their effects on phenotypes, we developed an approach to mapping structural variants that segregate in a population sequenced at low coverage. We avoid calling structural variants directly. Instead, the evidence for a potential structural variant at a locus is indicated by variation in the counts of short-reads that map anomalously to that locus. These structural variant traits are treated as quantitative traits and mapped genetically, analogously to a gene expression study. Association between a structural variant trait at one locus, and genotypes at a distant locus indicate the origin and target of a transposition. Using ultra-low-coverage (0.3×) population sequence data from 488 recombinant inbred

Indexed as

Genomic Structural VariationQuantitative Trait, HeritableArabidopsisPhenotypePlant ImmunityQuantitative Trait LociArabidopsisheritabilitylow-coverage sequencingquantitative trait locusstructural variation

Identifiers

PMID28179367
PMCPMC5378104

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.