Evidence map›Paper›PMID 28179280›Full record

ReviewBlood2017

GATA factor mutations in hematologic disease.

John D Crispino, Marshall S Horwitz

Open access · bronzeAbstract readReview
In one paragraph

Review in Blood, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed, 1 pooled it
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

123 citing papers in PubMed, 1 synthesis or guideline pooled it, 187 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. DiTSim: A Diffusion-Transformers Based Single-Cell ATAC-seq Data Simulator.Interdisciplinary sciences, computational life sciences · 2026
    Article
  6. Article
  7. The Mutational Landscape of Acute Myeloid Leukemia and Its Impact.International journal of molecular sciences · 2026
    Review
  8. A novelHaematologica · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. mInternational journal of molecular sciences · 2025
    Article
  14. Review
  15. Decoding the Implications of Zinc in the Development and Therapy of Leukemia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

63 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

John D CrispinoDivision of Hematology/Oncology, Northwestern University, Chicago, IL; and.
Marshall S HorwitzDepartment of Pathology, University of Washington School of Medicine, Seattle, WA.
Northwestern University · USUniversity of Washington · US

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9M
Mechanisms of Leukemogenesis in Down SyndromeR01CA101774 · NCI · UNIVERSITY OF CHICAGO · PI CRISPINO, JOHN D · 2003 to 2021
$6.1M
Pathogenesis of ELANE-Associated NeutropeniaR01HL130472 · NHLBI · UNIVERSITY OF WASHINGTON · PI HORWITZ, MARSHALL S. · 2016 to 2019
$1.7M
GATA1 Mutation in Defective ErythropoiesisR01DK101329 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CRISPINO, JOHN D · 2013 to 2017
$1.7M
NCI NIH HHS P30 CA060553NCI NIH HHS R01 CA101774NHLBI NIH HHS R01 HL130472NIDDK NIH HHS R01 DK101329
6 · The paper itself

Abstract

GATA family proteins play essential roles in development of many cell types, including hematopoietic, cardiac, and endodermal lineages. The first three factors, GATAs 1, 2, and 3, are essential for normal hematopoiesis, and their mutations are responsible for a variety of blood disorders. Acquired and inherited

Indexed as

GATA1 Transcription FactorGATA2 Transcription FactorHematologic DiseasesHematopoiesisMutationAnemia, Diamond-BlackfanAnimalsHumansGATA1 protein, humanGATA1 Transcription FactorGATA2 protein, humanGATA2 Transcription Factor

Identifiers

PMID28179280
PMCPMC5391620
OpenAlexW2587454956

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.