Evidence map›Paper›PMID 28179256›Full record

ArticleAmerican journal of physiology. Renal physiology2017

Zebrafish mesonephric renin cells are functionally conserved and comprise two distinct morphological populations.

Sebastien A Rider, Helen C Christian, Linda J Mullins, Amelia R Howarth, Calum A MacRae, John J Mullins

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Renin Cells, the Kidney, and Hypertension.Circulation research · 2021
    Review
  4. Phylogeny and ontogeny of the renin-angiotensin system: Current view and perspectives.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2021
    Review
  5. Article
  6. Review
  7. Ontogeny of renin gene expression in the chicken, Gallus gallus.General and comparative endocrinology · 2020
    Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Juxtaglomerular Cell Phenotypic Plasticity.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2017
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Sebastien A RiderUniversity/British Heart Foundation Centre for Cardiovascular Science, The Queen's Medical Research Institute, Little France, The University of Edinburgh, Edinburgh, United Kingdom; srider@staffmail.ed.ac.uk.ORCID 0000-0002-1020-4002
Helen C ChristianDepartment of Physiology, Anatomy and Genetics, Oxford, United Kingdom; and.
Linda J MullinsUniversity/British Heart Foundation Centre for Cardiovascular Science, The Queen's Medical Research Institute, Little France, The University of Edinburgh, Edinburgh, United Kingdom.
Amelia R HowarthUniversity/British Heart Foundation Centre for Cardiovascular Science, The Queen's Medical Research Institute, Little France, The University of Edinburgh, Edinburgh, United Kingdom.
Calum A MacRaeCardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
John J MullinsUniversity/British Heart Foundation Centre for Cardiovascular Science, The Queen's Medical Research Institute, Little France, The University of Edinburgh, Edinburgh, United Kingdom.
British Heart Foundation · GBBrigham and Women's Hospital · US

Funding

A Community Zebrafish Resource for Modeling GWAS BiologyR24OD017870 · OD · BRIGHAM AND WOMEN'S HOSPITAL · PI GOESSLING, WOLFRAM, MACRAE, CALUM A. · 2014 to 2021
$6.3M
British Heart FoundationNIH HHS R24 OD017870
6 · The paper itself

Abstract

Zebrafish provide an excellent model in which to assess the role of the renin-angiotensin system in renal development, injury, and repair. In contrast to mammals, zebrafish kidney organogenesis terminates with the mesonephros. Despite this, the basic functional structure of the nephron is conserved across vertebrates. The relevance of teleosts for studies relating to the regulation of the renin-angiotensin system was established by assessing the phenotype and functional regulation of renin-expressing cells in zebrafish. Transgenic fluorescent reporters for renin (

Indexed as

Cell ShapeRenin-Angiotensin SystemActinsAnimalsAnimals, Genetically ModifiedGene Expression Regulation, DevelopmentalGenotypeGreen Fluorescent ProteinsMicroscopy, FluorescenceMyocytes, Smooth MusclePericytesPhenotypeReceptor, Platelet-Derived Growth Factor betaRecombinant Fusion ProteinsReninTranscription, GeneticActinsenhanced green fluorescent proteinGreen Fluorescent ProteinsReceptor, Platelet-Derived Growth Factor betaRecombinant Fusion ProteinsReninZebrafish Proteinskidney injuryperivascularreninrenin-angiotensin systemzebrafish

Identifiers

PMID28179256
PMCPMC5407072
OpenAlexW2587413847

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.