ArticleBMC pulmonary medicine2017
Hemodynamic effects of lung recruitment maneuvers in acute respiratory distress syndrome.
Article in BMC pulmonary medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04297397 (Personalised Simulation Technologies for Optimising Treatment in the Intensive Care Unit), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Personalised Simulation Technologies for Optimising Treatment in the Intensive Care Unit
Who cites it
21 citing papers in PubMed, 48 citations in OpenAlex.
- Effects of intraoperative open-lung strategy on cardiopulmonary function in frail elderly patients undergoing laparoscopic surgery: a randomized controlled trial.BMC surgery · 2025Trial
- Alveolar Recruitment Maneuver Reduces Cerebral Oxygen Saturation and Cerebral Blood Flow Velocity in Patients During Carotid Endarterectomy.Medical science monitor : international medical journal of experimental and clinical research · 2021Trial
- Computational tools for personalizing treatment of acute respiratory failure, from machine learning to digital twins: a narrative review.Critical care (London, England) · 2026Review
- Effects of Lung-Protective Ventilation on Cerebral Oxygenation During One-Lung Ventilation in Neonates.Journal of pain research · 2026Article
- Study on the application of prone and supine lung recruitment maneuvers in the treatment of atelectasis after minimally invasive direct coronary artery bypass surgery.Frontiers in surgery · 2025Article
- Digital twins for chronic lung diseases.European respiratory review : an official journal of the European Respiratory Society · 2024Review
- The left ventricle in well newborns versus those with perinatal asphyxia, haemodynamically significant ductus arteriosus or fetal growth restriction.Translational pediatrics · 2023Review
- A systematic review of cardiacProgress in biomedical engineering (Bristol, England) · 2023Review
- Shortened Automatic Lung Recruitment Maneuvers in an In Vivo Model of Neonatal ARDS.Respiratory care · 2023Article
- Individualizing Fluid Management in Patients with Acute Respiratory Distress Syndrome and with Reduced Lung Tissue Due to Surgery-A Narrative Review.Journal of personalized medicine · 2023Review
- Hemodynamic consequences of respiratory interventions in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2022Review
- Simulation to minimise patient self-inflicted lung injury: are we almost there?British journal of anaesthesia · 2022Article
- Prediction of Fluid Responsiveness by the Effect of the Lung Recruitment Maneuver on the Perfusion Index in Mechanically Ventilated Patients During Surgery.Frontiers in medicine · 2022Article
- Selective Lobe Ventilation and a Novel Platform for Pulmonary Drug Delivery.Journal of cardiothoracic and vascular anesthesia · 2021Review
- High risk of patient self-inflicted lung injury in COVID-19 with frequently encountered spontaneous breathing patterns: a computational modelling study.Annals of intensive care · 2021Article
- In Silico Modeling of Coronavirus Disease 2019 Acute Respiratory Distress Syndrome: Pathophysiologic Insights and Potential Management Implications.Critical care explorations · 2020Article
- Effect of oxygen fraction on airway rescue: a computational modelling study.British journal of anaesthesia · 2020Article
- Management of primary blast lung injury: a comparison of airway pressure release versus low tidal volume ventilation.Intensive care medicine experimental · 2020Article
- Inhaled epoprostenol utilization pattern after implementation of an administration policy.Proceedings (Baylor University. Medical Center) · 2020Article
- What links ventilator driving pressure with survival in the acute respiratory distress syndrome? A computational study.Respiratory research · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClinical trials have, so far, failed to establish clear beneficial outcomes of recruitment maneuvers (RMs) on patient mortality in acute respiratory distress syndrome (ARDS), and the effects of RMs on the cardiovascular system remain poorly understood.
methodsA computational model with highly integrated pulmonary and cardiovascular systems was configured to replicate static and dynamic cardio-pulmonary data from clinical trials. Recruitment maneuvers (RMs) were executed in 23 individual in-silico patients with varying levels of ARDS severity and initial cardiac output. Multiple clinical variables were recorded and analyzed, including arterial oxygenation, cardiac output, peripheral oxygen delivery and alveolar strain.
resultsThe maximal recruitment strategy (MRS) maneuver, which implements gradual increments of positive end expiratory pressure (PEEP) followed by PEEP titration, produced improvements in PF ratio, carbon dioxide elimination and dynamic strain in all 23 in-silico patients considered. Reduced cardiac output in the moderate and mild in silico ARDS patients produced significant drops in oxygen delivery during the RM (average decrease of 423 ml min
conclusionsOur results support the hypothesis that patients with severe ARDS and significant numbers of alveolar units available for recruitment may benefit more from RMs. Our results also indicate that a higher than normal initial cardiac output may provide protection against the potentially negative effects of high intrathoracic pressures associated with RMs on cardiac function. Results from in silico patients with mild or moderate ARDS suggest that the detrimental effects of RMs on cardiac output can potentially outweigh the positive effects of alveolar recruitment on oxygenation, resulting in overall reductions in tissue oxygen delivery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.