Evidence map›Paper›PMID 28178939›Full record

ArticleBMC ophthalmology2017

Corneal vesicles accumulate collagen VI associated with tissue remodeling in apolipoprotein a-I deficiency: a case report.

Hiroyuki Namba, Mari Narumi, Shinji Susa, Rintaro Ohe, Takeo Kato, Mitsunori Yamakawa, Hidetoshi Yamashita

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hiroyuki NambaDepartment of Ophthalmology and Visual Sciences, Yamagata University Faculty of Medicine, 2-2-2 Iidanishi, 9909585, Yamagata City, Yamagata, Japan. h-nanba@med.id.yamagata-u.ac.jp.ORCID http://orcid.org/0000-0002-3879-7970
Mari NarumiDepartment of Ophthalmology and Visual Sciences, Yamagata University Faculty of Medicine, 2-2-2 Iidanishi, 9909585, Yamagata City, Yamagata, Japan.
Shinji SusaDepartment of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Yamagata City, Yamagata, Japan.
Rintaro OheDepartment of Diagnostic Pathology, Yamagata University Faculty of Medicine, Yamagata City, Yamagata, Japan.
Takeo KatoDepartment of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Yamagata City, Yamagata, Japan.
Mitsunori YamakawaDepartment of Diagnostic Pathology, Yamagata University Faculty of Medicine, Yamagata City, Yamagata, Japan.
Hidetoshi YamashitaDepartment of Ophthalmology and Visual Sciences, Yamagata University Faculty of Medicine, 2-2-2 Iidanishi, 9909585, Yamagata City, Yamagata, Japan.
Yamagata University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundApo A-I deficiency clinically shows low serum levels of HDL cholesterol and corneal opacity at a young age. Histopathological evaluations of affected corneas are not enough, and the mechanism of corneal opacity is still unclear. CASE PRESENTATION: A 61-year-old woman suffered from blurred vision with a corneal opacity. She had significantly reduced serum levels of high-density lipoprotein cholesterol and Apo A-I, stenosis of the coronary arteries, and ischemic heart failure. On genetic examination, a homozygous mutation of Apo A-I

conclusionWe experienced a rare case of corneal opacity due to Apo A-I deficiency. Our histopathological findings indicated that structural changes in corneal collagen fibrils contribute to the formation of stromal vesicles.

Indexed as

Apolipoprotein A-ICollagen Type VICorneaCorneal OpacityDyslipidemiasFemaleHumansImmunohistochemistryMicroscopy, ConfocalMiddle AgedApolipoprotein A-ICollagen Type VIApolipoprotein a-I deficiencyCase reportCollagen VIConfocal microscopyCorneal opacityImmunohistochemistry

Identifiers

PMID28178939
PMCPMC5299694
OpenAlexW2586842980

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.