Evidence map›Paper›PMID 28178737›Full record

ArticlePloS one2017

HIV-1 molecular epidemiology among newly diagnosed HIV-1 individuals in Hebei, a low HIV prevalence province in China.

Xinli Lu, Xianjiang Kang, Yongjian Liu, Ze Cui, Wei Guo, Cuiying Zhao, Yan Li, Suliang Chen, Jingyun Li, Yuqi Zhang and 1 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Xinli LuCollege of Life Science, Hebei University, Baoding, Hebei, China.
Xianjiang KangCollege of Life Science, Hebei University, Baoding, Hebei, China.
Yongjian LiuDepartment of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Ze CuiHebei Provincial Center for Disease Control and Prevention, Shjiazhuang, Hebei, China.
Wei GuoNO. 201 hospital of the People's Liberation Army of China, Liaoyang, Liaoning, China.
Cuiying ZhaoHebei Provincial Center for Disease Control and Prevention, Shjiazhuang, Hebei, China.
Yan LiHebei Provincial Center for Disease Control and Prevention, Shjiazhuang, Hebei, China.
Suliang ChenHebei Provincial Center for Disease Control and Prevention, Shjiazhuang, Hebei, China.
Jingyun LiDepartment of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Yuqi ZhangHebei Provincial Center for Disease Control and Prevention, Shjiazhuang, Hebei, China.
Hongru ZhaoHebei Provincial Center for Disease Control and Prevention, Shjiazhuang, Hebei, China.
Hebei Provincial Center for Disease Control and Prevention · CNHebei University · CNInstitute of Microbiology · CNPeople's Liberation Army No. 150 Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

New human immunodeficiency virus type 1 (HIV-1) diagnoses are increasing rapidly in Hebei. The aim of this study presents the most extensive HIV-1 molecular epidemiology investigation in Hebei province in China thus far. We have carried out the most extensive systematic cross-sectional study based on newly diagnosed HIV-1 positive individuals in 2013, and characterized the molecular epidemiology of HIV-1 based on full length gag-partial pol gene sequences in the whole of Hebei. Nine HIV-1 genotypes based on full length gag-partial pol gene sequence were identified among 610 newly diagnosed naïve individuals. The four main genotypes were circulating recombinant form (CRF)01_AE (53.4%), CRF07_BC (23.4%), subtype B (15.9%), and unique recombinant forms URFs (4.9%). Within 1 year, three new genotypes (subtype A1, CRF55_01B, CRF65_cpx), unknown before in Hebei, were first found among men who have sex with men (MSM). All nine genotypes were identified in the sexually contracted HIV-1 population. Among 30 URFs, six recombinant patterns were revealed, including CRF01_AE/BC (40.0%), CRF01_AE/B (23.3%), B/C (16.7%), CRF01_AE/C (13.3%), CRF01_AE/B/A2 (3.3%) and CRF01_AE/BC/A2 (3.3%), plus two potential CRFs. This study elucidated the complicated characteristics of HIV-1 molecular epidemiology in a low HIV-1 prevalence northern province of China and revealed the high level of HIV-1 genetic diversity. All nine HIV-1 genotypes circulating in Hebei have spread out of their initial risk groups into the general population through sexual contact, especially through MSM. This highlights the urgency of HIV prevention and control in China.

Indexed as

AdolescentAdultAgedCD4 Lymphocyte CountChildChild, PreschoolChinaFemaleGenotypeHIV-1HIV InfectionsHumansInfantInfant, NewbornMaleMiddle AgedRNA, Viral

Identifiers

PMID28178737
PMCPMC5298910
OpenAlexW2587730924

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.