ArticleOncotarget2017
Identification of distinct molecular subtypes of uterine carcinosarcoma.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Identification of Distinct Molecular Subtypes of Endometrioid Adenocarcinoma.Frontiers in genetics · 2021Article
- Gene expression profile identifies distinct molecular subtypes and potential therapeutic genes in Merkel cell carcinoma.Translational oncology · 2020Article
- Article
- Gene Expression Profiling Reveals Distinct Molecular Subtypes of Esophageal Squamous Cell Carcinoma in Asian Populations.Neoplasia (New York, N.Y.) · 2019Article
- Molecular classification and subtype-specific drug sensitivity research of uterine carcinosarcoma under multi-omics framework.Cancer biology & therapy · 2019Article
- Distinct esophageal adenocarcinoma molecular subtype has subtype-specific gene expression and mutation patterns.BMC genomics · 2018Article
- Distinct molecular subtypes of uterine leiomyosarcoma respond differently to chemotherapy treatment.BMC cancer · 2017Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Uterine carcinosarcoma (UCS) is a rare but lethal neoplasm with high metastasis and recurrence rate, and to date, no molecular classification of UCS has been defined to achieve targeted therapies. In this study, we identified two distinct molecular subtypes of UCS with distinct gene expression patterns and clinicopathologic characteristics. Subtype I UCS recapitulates low-grade UCS, in contrast subtype II UCS represents high-grade UCS with higher tumor invasion rate and tumor weight. Interestingly, subtype I UCS is characterized by cell adhesion and apoptosis pathways, whereas genes over-expressed in subtype II UCS are more involved in myogenesis/muscle development. We also proposed certain potential subtype specific therapeutic targets, such as SYK (spleen tyrosine kinase) for subtype I and cell-cycle proteins for subtype II. Our findings provide a better recognition of UCS molecular subtypes and subtype specific oncogenesis mechanisms, and can help develop more specific targeted treatment options for these tumors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.