Evidence map›Paper›PMID 28178565›Full record

ReviewCell metabolism2017

Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics.

Patrycja Puchalska, Peter A Crawford

2 registry-linked trialsOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 936 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
936citing papers in PubMed, 6 pooled it
56.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04360148 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Randomized-controlled Study for Evaluation of Ketogenic Metabolic Nutritional Pattern in Subjects With High-frequency Episodic Migraine

TypeinterventionalSponsorNew Penta SRLRan2020 to 2021Enrolled58ConditionsMigraine, Ketogenic Dieting, Weight Loss, OverweightArmsvery-low-calorie-ketogenic-diet, hypocaloric-balanced-diet
NCT05615883 nacompletednot on this mapstarted 2020, after this paper: background citation

Effects of Acute and Chronic Exercise on Myeloid-Derived Suppressor Cells in Melanoma Patients

TypeinterventionalSponsorFondazione IRCCS Istituto Nazionale dei Tumori, MilanoRan2020 to 2023Enrolled16ConditionsMelanomaArmsAEP Group Walking Sessions, CEP Group Walking Sessions
3 · Its place in the literature

Who cites it

936 citing papers in PubMed, 6 syntheses or guidelines pooled it, 1,528 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Review
  16. Review
  17. Maternal Health and Kidney Function in Offspring.Journal of the American Society of Nephrology : JASN · 2026
    Article
  18. Acute Heat Exposure Upregulates Zebra Finch Physiology While Avoiding DNA Damage Across Both Sexes.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2026
    Article
  19. Article
  20. Article

876 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Patrycja PuchalskaCenter for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL 32827, USA.
Peter A CrawfordCenter for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL 32827, USA. Electronic address: pcrawford@sbpdiscovery.org.
Discovery Institute · USSanford Burnham Prebys Medical Discovery Institute · US

Funding

KETONE BODY METABOLISM AND INTEGRATED METABOLIC HOMEOSTASISR01DK091538 · NIDDK · WASHINGTON UNIVERSITY · PI CRAWFORD, PETER A · 2011 to 2024
$6.2M
NIDDK NIH HHS R01 DK091538
6 · The paper itself

Abstract

Ketone body metabolism is a central node in physiological homeostasis. In this review, we discuss how ketones serve discrete fine-tuning metabolic roles that optimize organ and organism performance in varying nutrient states and protect from inflammation and injury in multiple organ systems. Traditionally viewed as metabolic substrates enlisted only in carbohydrate restriction, observations underscore the importance of ketone bodies as vital metabolic and signaling mediators when carbohydrates are abundant. Complementing a repertoire of known therapeutic options for diseases of the nervous system, prospective roles for ketone bodies in cancer have arisen, as have intriguing protective roles in heart and liver, opening therapeutic options in obesity-related and cardiovascular disease. Controversies in ketone metabolism and signaling are discussed to reconcile classical dogma with contemporary observations.

Indexed as

Energy MetabolismSignal TransductionAnimalsHepatocytesHumansKetone BodiesNeoplasmsNeuroprotectionKetone Bodiesalternative fuelcancer metabolismcarbohydrate restrictioncardiac metabolismextrahepatic ketogenesisfuel metabolismHMGCS2ketogenic dietmitochondrial functionNAFLDSCOT

Identifiers

PMID28178565
PMCPMC5313038
OpenAlexW2587156779

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.