Evidence map›Paper›PMID 28178445›Full record

ArticleeLife2017

A long-term epigenetic memory switch controls bacterial virulence bimodality.

Irine Ronin, Naama Katsowich, Ilan Rosenshine, Nathalie Q Balaban

Abstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Phylogroup Homeostasis ofMicroorganisms · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. GrlR, a negative regulator in enteropathogenicFrontiers in microbiology · 2023
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Why do plasmids manipulate the expression of bacterial phenotypes?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Review
  20. Transcriptional Profiling of Pseudomonas aeruginosa Infections.Advances in experimental medicine and biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Irine RoninRacah Institute of Physics, Edmond J. Safra Campus, Faculty of Science, The Hebrew University of Jerusalem, Jerusalem, Israel.
Naama KatsowichDepartment of Microbiology and Molecular Genetics, IMRIC, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Ilan RosenshineDepartment of Microbiology and Molecular Genetics, IMRIC, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Nathalie Q BalabanRacah Institute of Physics, Edmond J. Safra Campus, Faculty of Science, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID 0000-0001-8018-0766

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

When pathogens enter the host, sensing of environmental cues activates the expression of virulence genes. Opposite transition of pathogens from activating to non-activating conditions is poorly understood. Interestingly, variability in the expression of virulence genes upon infection enhances colonization. In order to systematically detect the role of phenotypic variability in enteropathogenic

Indexed as

Epigenesis, GeneticEscherichia coliModels, TheoreticalVirulenceVirulence FactorsVirulence Factorsbimodal gene expressioncomputational biologyE. coliEPEChysteresisinfectious diseasemicrobiologynon-genetic variabilityPerABCsystems biologyvirulence regulation

Identifiers

PMID28178445
PMCPMC5295817

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.