ArticlePloS one2017
A simple prediction score system for malignant brain edema progression in large hemispheric infarction.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Predictive power of artificial intelligence for malignant cerebral edema in stroke patients: a CT-based systematic review and meta-analysis of prevalence and diagnostic performance.Neurosurgical review · 2025Pooled it
- Risk prediction models for malignant cerebral edema after endovascular therapy in patients with acute anterior circulation large vessel occlusion stroke: a systematic review and meta-analysis.Frontiers in neurologyPooled it
- Association of Reperfusion With Brain Edema in Patients With Acute Ischemic Stroke: A Secondary Analysis of the MR CLEAN Trial.JAMA neurology · 2018Trial
- Malignant Cerebral Edema after Large-Core Anterior Circulation Stroke in the Thrombectomy Era: Prediction and Neurocritical Care Pathways.Neurocritical care · 2026Review
- Association of Blood-Based Biomarkers and Malignant Infarction in Severe Anterior Circulation Ischemic Stroke.Brain and behavior · 2026Article
- A nomogram for predicting malignant middle cerebral artery infarction after thrombectomy in large core infarction.Neuroradiology · 2026Article
- Development of the SIMPLE scoring system for predicting malignant brain edema in patients with large hemispheric infarction following acute ischemic stroke.Neurosurgical review · 2026Article
- Development and internal validation of a multimodal nomogram integrating clinical, imaging, and laboratory data to predict malignant brain edema after reperfusion in acute ischemic stroke.Quantitative imaging in medicine and surgery · 2026Article
- The malignant stroke indicator is an early indicator of malignant ischemic stroke requiring decompressive hemicraniectomy.Scientific reports · 2025Observational
- Hypoperfusion Intensity Ratio as an Indirect Imaging Surrogate in Patients With Anterior Circulation Large-Vessel Occlusion and Association of Baseline Characteristics With Poor Collateral Status.Journal of the American Heart Association · 2024Article
- Updates in Management of Large Hemispheric Infarct.Seminars in neurology · 2024Review
- Validation and refinement of a predictive nomogram using artificial intelligence: assessing in-hospital mortality in patients with large hemispheric cerebral infarction.Frontiers in neurology · 2024Article
- A CT-based machine learning model for using clinical-radiomics to predict malignant cerebral edema after stroke: a two-center study.Frontiers in neuroscience · 2024Article
- Performance comparison of stress hyperglycemia ratio for predicting fatal outcomes in patients with thrombolyzed acute ischemic stroke.PloS one · 2024Article
- The ACORNS grading scale: a novel tool for the prediction of malignant brain edema after endovascular thrombectomy.Journal of neurointerventional surgery · 2023Article
- Predicting the emergence of malignant brain oedema in acute ischaemic stroke: a prospective multicentre study with development and validation of predictive modelling.EClinicalMedicine · 2023Article
- Serum S-100B adds incremental value for the prediction of symptomatic intracranial hemorrhage and brain edema after acute ischemic stroke.European stroke journal · 2023Article
- Development and validation of a nomogram for the risk prediction of malignant cerebral edema after acute large hemispheric infarction involving the anterior circulation.Frontiers in neurology · 2023Article
- Predictors and Dynamic Nomogram to Determine the Individual Risk of Malignant Brain Edema After Endovascular Thrombectomy in Acute Ischemic Stroke.Journal of clinical neurology (Seoul, Korea) · 2022Article
- Trends in mechanical thrombectomy and decompressive hemicraniectomy for stroke: A multicenter study.The neuroradiology journal · 2022Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malignant brain edema (MBE) due to hemispheric infarction can result in brain herniation, poor outcomes, and death; outcome may be improved if certain interventions, such as decompressive craniectomy, are performed early. We sought to generate a prediction score to easily identify those patients at high risk for MBE. 121 patients with large hemispheric infarction (LHI) (2011 to 2014) were included. Patients were divided into two groups: those who developed MBE and those who did not. Independent predictors of MBE were identified by logistic regression and a score was developed. Four factors were independently associated with MBE: baseline National Institutes of Health Stroke Scale (NIHSS) score (p = 0.048), Alberta Stroke Program Early Computed Tomography Score (ASPECTS) (p = 0.007), collateral score (CS) (p<0.001) and revascularization failure (p = 0.013). Points were assigned for each factor as follows: NIHSS ≤ 8 (= 0), 9-17 (= 1), ≥ 18 (= 2); ASPECTS≤ 7 (= 1), >8 (= 0); CS<2 (= 1), ≥2 (= 0); revascularization failure (= 1),success (= 0). The MBE Score (MBES) represents the sum of these individual points. Of 26 patients with a MBES of 0 to 1, none developed MBE. All patients with a MBES of 6 developed MBE. Both MBE development and functional outcomes were strongly associated with the MBES (p = 0.007 and 0.002, respectively). The MBE score is a simple reliable tool for the prediction of MBE.
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