SynthesisPloS one2017
Herpes zoster and the risk of ischemic and hemorrhagic stroke: A systematic review and meta-analysis.
Synthesis in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Herpesvirus latent infection promotes stroke via activating the OTUD1/NF-κB signaling pathway.Aging · 2023Pooled it
- Pooled it
- A systematic review and meta-analysis on herpes zoster and the risk of cardiac and cerebrovascular events.PloS one · 2017Pooled it
- Keeping An Eye Out for Stroke-Herpes Zoster Ophthalmicus Leading to Acute Ischemic Stroke.Clinical practice and cases in emergency medicine · 2026Article
- Review
- Microvascular Density Analysis of Patients with Trigeminal Herpes Zoster-An Optical Coherence Tomography Angiography Study.Biomedicines · 2025Article
- Increase in Adult Patients with Varicella Zoster Virus-Related Central Nervous System Infections, Japan.Emerging infectious diseases · 2024Article
- Herpes Zoster and Cardiovascular Disease: Exploring Associations and Preventive Measures through Vaccination.Vaccines · 2024Review
- Herpes zoster associated with stroke incidence in people living with human immunodeficiency virus: a nested case-control study.BMC infectious diseases · 2023Article
- Cross-Sectional Retrospective Study to Identify Clinical and Radiographic Features Associated With VZV Reactivation in Cryptogenic Stroke Patients With CSF Testing.The Neurohospitalist · 2022Article
- Herpes Zoster Vaccine Live and Risk of Stroke Among Medicare Beneficiaries: A Population-Based Cohort Study.Stroke · 2021Article
- Herpesvirus infections, antiviral treatment, and the risk of dementia-a registry-based cohort study in Sweden.Alzheimer's & dementia (New York, N. Y.) · 2021Article
- Does Herpes Zoster Increase the Risk of Stroke and Myocardial Infarction? A Comprehensive Review.Journal of clinical medicine · 2019Review
- Herpes Zoster: Epidemiological Links With Stroke and Myocardial Infarction.The Journal of infectious diseases · 2018Article
- Varicella Zoster Virus Vasculopathy.The Journal of infectious diseases · 2018Article
- Post-Varicella Neurological Complications: A Preliminary Observation from a Tertiary Care Centre of Eastern India.Annals of Indian Academy of NeurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHerpes zoster infection and stroke are highly prevalent in the general population; however, reports have presented inconsistent findings regarding the relationship between herpes zoster infection and stroke. In this meta-analysis, we aimed to clarify this association. MATERIAL AND
methodsThe PubMed and Embase databases were searched for studies published from their inception to January 2016. Two investigators independently extracted the data. The pooled relative risk (RR) was calculated using a random effects model.
resultsA total of 8 studies met the inclusion criteria. During the first 1 month after herpes zoster infection, the pooled RRs for ischemic stroke and hemorrhagic stroke were 1.55 (95% CI, 1.46-1.65) and 1.70 (95% CI, 0.73-3.96), respectively, and within 3 months after infection, the corresponding RRs were 1.17 (95% CI, 1.12-1.23) and 2.05 (95% CI, 1.17-3.60), respectively. At 1 year and more than 1 year after herpes zoster infection, a significant relationship was not observed between herpes zoster infection and the incidence of ischemic and hemorrhagic stroke. Publication bias was not observed.
conclusionThe accumulated evidence generated from this systematic review indicates that an increased risk for ischemic stroke occurred in the short term after herpes zoster infection, whereas a significant relationship was not observed in the long term after infection. With respect to hemorrhagic stroke, the association was not significant. With respect to hemorrhagic stroke, the association between was not significant except within 3 months after a herpes zoster infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.