ArticlePloS one2017
Purification, characterization, and antitumor activity of a novel glucan from the fruiting bodies of Coriolus Versicolor.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 45 citations in OpenAlex.
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- COVID-19 and Cancer Diseases-The Potential ofInternational journal of molecular sciences · 2023Review
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- Fungal Mushrooms: A Natural Compound With Therapeutic Applications.Frontiers in pharmacology · 2022Review
- Mushrooms as Potential Sources of Active Metabolites and Medicines.Frontiers in microbiology · 2022Review
- Genoprotective activity of theFrontiers in nutrition · 2022Article
- Medicinal Properties and Bioactive Compounds from Wild Mushrooms Native to North America.Molecules (Basel, Switzerland) · 2021Review
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- Metastatic Cardiac Hemangiosarcoma in a 6 Year Old Wheaten Terrier Mix.Veterinary sciences · 2019Article
- Medicinal mushrooms as an attractive new source of natural compounds for future cancer therapy.Oncotarget · 2018Review
- Effect ofBiomedical reports · 2017Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer is one of the most common causes of deaths worldwide. Herein, we report an efficient natural anticancer glucan (CVG) extracted from Coriolus Versicolar (CV). CVG was extracted by the hot water extraction method followed by ethanol precipitation and purified using gas exclusion chromatography. Structural analysis revealed that CVG has a linear α-glucan chain composed of only (1→ 6)-α-D-Glcp. The antitumor activity of CVG on Sarcoma-180 cells was investigated in vitro and in vivo. Mice were treated with three doses of CVG (40, 100, 200 mg/kg body weight) for 9 days. Tumor weight, relative spleen, thymus weight, and lymphocyte proliferation were studied. A significant increase (P< 0.01) in relative spleen and thymus weight and a decrease (P< 0.01) in tumor weight at the doses of 100 and 200 mg/kg were observed. The results obtained demonstrate CVG has antitumor activity towards Sarcoma-180 cells by its immunomodulation activity.
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Registered trials
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