Evidence map›Paper›PMID 28178205›Full record

ArticleNutrients2017

Gluten Contamination in Naturally or Labeled Gluten-Free Products Marketed in Italy.

Anil K Verma, Simona Gatti, Tiziana Galeazzi, Chiara Monachesi, Lucia Padella, Giada Del Baldo, Roberta Annibali, Elena Lionetti, Carlo Catassi

Registry-linked trialAbstract read
In one paragraph

Article in Nutrients, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04477239 (A Randomized, Triple-blind, Placebo-controlled, Clinical Trial on the Diagnostic Performance of Gluten Immunogenic Peptides in the Evaluation of Gluten-free Diet Adherence), which is not on this map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04477239 nacompletednot on this mapstarted 2020, after this paper: background citation

A Randomized, Triple-blind, Placebo-controlled, Clinical Trial on the Diagnostic Performance of Gluten Immunogenic Peptides in the Evaluation of Gluten-free Diet Adherence: the GRRES Study.

TypeinterventionalSponsorUniversità Politecnica delle MarcheRan2020 to 2020Enrolled25ConditionsCeliac DiseaseArmsGluten (behaviour), Placebo (behaviour)
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Celiac Disease: Risks of Cross-Contamination and Strategies for Gluten Removal in Food Environments.International journal of environmental research and public health · 2024
    Review
  10. Review
  11. Review
  12. The global burden of coeliac disease: opportunities and challenges.Nature reviews. Gastroenterology & hepatology · 2022
    Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Observational
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anil K VermaCeliac Disease Research Laboratory, Department of Pediatrics, Università Politecnica delle Marche, 60123 Ancona, Italy. anilkrvermaa@gmail.com.
Simona GattiCeliac Disease Research Laboratory, Department of Pediatrics, Università Politecnica delle Marche, 60123 Ancona, Italy. simona.gatti@hotmail.it.
Tiziana GaleazziCeliac Disease Research Laboratory, Department of Pediatrics, Università Politecnica delle Marche, 60123 Ancona, Italy. t.galeazzi@univpm.it.
Chiara MonachesiCeliac Disease Research Laboratory, Department of Pediatrics, Università Politecnica delle Marche, 60123 Ancona, Italy. chiara.monachesi28@gmail.com.
Lucia PadellaCeliac Disease Research Laboratory, Department of Pediatrics, Università Politecnica delle Marche, 60123 Ancona, Italy. luciapadella@libero.it.
Giada Del BaldoDepartment of Pediatrics, Università Politecnica delle Marche, 60123 Ancona, Italy. giadadelbaldo@gmail.com.
Roberta AnnibaliDepartment of Pediatrics, Università Politecnica delle Marche, 60123 Ancona, Italy. robertannibali@hotmail.it.
Elena LionettiCeliac Disease Research Laboratory, Department of Pediatrics, Università Politecnica delle Marche, 60123 Ancona, Italy. mariaelenalionetti@gmail.com.
Carlo CatassiCeliac Disease Research Laboratory, Department of Pediatrics, Università Politecnica delle Marche, 60123 Ancona, Italy. c.catassi@univpm.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA strict and lifelong gluten-free diet is the only treatment of celiac disease. Gluten contamination has been frequently reported in nominally gluten-free products. The aim of this study was to test the level of gluten contamination in gluten-free products currently available in the Italian market.

methodA total of 200 commercially available gluten-free products (including both naturally and certified gluten-free products) were randomly collected from different Italian supermarkets. The gluten content was determined by the R5 ELISA Kit approved by EU regulations.

resultsGluten level was lower than 10 part per million (ppm) in 173 products (86.5%), between 10 and 20 ppm in 9 (4.5%), and higher than 20 ppm in 18 (9%), respectively. In contaminated foodstuff (gluten > 20 ppm) the amount of gluten was almost exclusively in the range of a very low gluten content. Contaminated products most commonly belonged to oats-, buckwheat-, and lentils-based items. Certified and higher cost gluten-free products were less commonly contaminated by gluten.

conclusionGluten contamination in either naturally or labeled gluten-free products marketed in Italy is nowadays uncommon and usually mild on a quantitative basis. A program of systematic sampling of gluten-free food is needed to promptly disclose at-risk products.

Indexed as

Food AnalysisEnzyme-Linked Immunosorbent AssayFood ContaminationGlutensItalyQuality ControlGlutensbuckwheatceliac diseasegluten-free productslentilsnaturally gluten-freeoatsR5 ELISA

Identifiers

PMID28178205
PMCPMC5331546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.