Observational studyMedicine2017
Blood mean platelet volume and platelet lymphocyte ratio as new predictors of hip osteoarthritis severity.
Observational study in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Pooled it
- Are Platelet Volume, Density, and the Homeostatic Blueprint the Missing Link in Platelet-Rich Plasma Therapies? An Evidence-Based Narrative Review.Journal of clinical medicine · 2026Review
- The Association Between Platelet Indices and Osteoarthritis: A Systematic Review and Meta-analysis.Clinical medicine insights. Arthritis and musculoskeletal disorders · 2026Article
- The onset inflammatory parameters and the Cobb angle in adolescent idiopathic scoliosis: a case-control study.Croatian medical journal · 2025Article
- Association between systemic Immune-inflammation index, systemic inflammation response index and adult osteoarthritis: national health and nutrition examination survey.BMC musculoskeletal disorders · 2025Article
- Is there a relationship between blood inflammation markers and the severity of knee osteoarthritis?Turkish journal of physical medicine and rehabilitation · 2025Article
- Platelet and Lymphocyte-Related Parameters as Potential Markers of Osteoarthritis Severity: A Cross-Sectional Study.Biomedicines · 2024Article
- Thrombocytosis in patients with spondyloarthritis: a case-control study.BMC musculoskeletal disorders · 2023Article
- The Value of the Monocyte to High-Density Lipoprotein Cholesterol Ratio in Assessing the Severity of Knee Osteoarthritis: A Retrospective Single Center Cohort Study.Journal of inflammation research · 2023Article
- Are inflammatory parameters an independent predictor of hip osteoarthritis severity? A prospective cross-sectional study.Revista da Associacao Medica Brasileira (1992) · 2022Article
- Clinical Cohort Study in Canine Patients, to Determine the Average Platelet and White Blood Cell Number and Its Correlation with Patient's Age, Weight, Breed and Gender: 92 Cases (2019-2020).Veterinary sciences · 2021Article
- Frequency, pattern, and associations of generalized osteoarthritis among Nigerians with knee osteoarthritis.Clinical rheumatology · 2021Article
- Potential Value of Matrix Metalloproteinase-13 as a Biomarker for Osteoarthritis.Frontiers in surgery · 2021Article
- Association between platelet count and osteoarthritis in women older than 50 years.Therapeutic advances in musculoskeletal disease · 2020Article
- Neutrophil to lymphocyte ratio and clinical outcomes in COPD: recent evidence and future perspectives.European respiratory review : an official journal of the European Respiratory Society · 2018Review
- Association between multimorbidity and mean platelet volume in diabetic patients with acute myocardial infarction.Acta diabetologica · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoarthritis (OA) is a low grade systemic inflammatory disease in which many inflammatory mediators are known to be elevated in the peripheric blood. Blood platelet lymphocyte ratio (PLR) and mean platelet volume (MPV) are accepted as novel markers in many of the systemic inflammatory disorders, but have not been investigated in synovitis-free radiographic OA yet.The aim of this study was to evaluate the levels of blood PLR and MPV in radiographic hip OA. A total of 880 patients were evaluated retrospectively and after certain exclusion criteria, 237 of them who have primary hip OA were included. Age, sex, height, weight, body mass index, neutrophil, lymphocyte and platelet counts, erythrocyte sedimentation rate (ESR), PLR, and MPV levels were recorded, Kellgren-Lawrence (KL) grading of the hip joints were performed. Patients were then divided into 2 groups as KL grades 1 to 2 (mild-moderate) and KL grades 3 to 4 (severe) hip OA.Mean age, mean neutrophil, lymphocyte and platelet counts, mean MPV, mean PLR, and mean ESR were statistically significantly different between mild/moderate hip OA group and severe hip OA group. In univariate analysis, older age and higher MPV, PLR, and ESR were severely associated with severe hip OA. In multiple logistic regression analysis, MPV, PLR, and ESR emerged as independent predictors of severe hip OA.The results of the present study, for the first time in the literature, suggest blood PLR and MPV as novel inflammatory markers predicting the radiographic severity of hip OA in the daily practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.